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Endothelial Dysfunction and Inflammation

Shauna Dauphinee, Aly Karsan (Herausgeber)

Buch | Hardcover

XII, 234 Seiten

2010 | 2010
Springer Basel (Verlag)
978-3-0346-0167-2 (ISBN)

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Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Endothelial activation and dysfunction in sepsis.- Heterogeneity in responses of microvascular endothelial cells during inflammation.- Oxidative stress and endothelial dysfunction.- Post-translational regulation of eNOS activity in inflammation.- Endothelial dysfunction in pulmonary hypertension.- Endothelial dysfunction in systemic hypertension.- Sphingosine-1-phosphate as a mediator of endothelial dysfunction during inflammation.- Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature.- AGE-RAGE signalling in endothelial dysfunction and atherosclerosis in diabetes.- Regional predisposition to atherosclerosis – An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells.- Inflammation and endothelial dysfunction with aging.- Clinical approaches to assess endothelial function in vivo.- Therapeutic approaches towards targeting endothelial dysfunction.

Erscheint lt. Verlag	16.9.2010
Reihe/Serie	Progress in Inflammation Research
Zusatzinfo	XII, 234 p.
Verlagsort	Basel
Sprache	englisch
Gewicht	700 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik)
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Activation • atherosclerosis • Endothelial Dysfunction • Hypertension • inflammation • Nitric oxide • Oxidative stress • Regulation • Sepsis • Sepsis / Blutvergiftung • vascular diseases
ISBN-10	3-0346-0167-0 / 3034601670
ISBN-13	978-3-0346-0167-2 / 9783034601672
Zustand	Neuware