The Coronaviridae

Buch | Hardcover

418 Seiten

1995
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-44972-7 (ISBN)

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Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.

1 The Coronaviridae: An Introduction.- 2 Coronavirus Replication, Transcription, and RNA Recombination.- 3 Coronavirus Gene Expression: Genome Organization and Protein Synthesis.- 4 Coronavirus Receptors.- 5 The Coronavirus Surface Glycoprotein.- 6 The Coronavirus Membrane Glycoprotein.- 7 The Coronavirus Nucleocapsid Protein.- 8 The Coronavirus Hemagglutinin Esterase Glycoprotein.- 9 The Small-Membrane Protein.- 10 The Coronavirus Nonstructural Proteins.- 11 The Molecular Biology of Toroviruses.- 12 The Coronaviruslike Superfamily.- 13 Pathogenesis and Diseases of the Central Nervous System Caused by Murine Coronaviruses.- 14 Feline Infectious Peritonitis.- 15 Epidemiology of Infectious Bronchitis Virus.- 16 Molecular Basis of Transmissible Gastroenteritis Virus Epidemiology.- 17 Pathogenesis of the Porcine Coronaviruses.- 18 Human Coronavirus Infections.- 19 The Pathogenesis of Torovirus Infections in Animals and Humans.

Erscheint lt. Verlag	30.9.1995
Reihe/Serie	The Viruses
Zusatzinfo	XVIII, 418 p.
Verlagsort	New York
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	0-306-44972-2 / 0306449722
ISBN-13	978-0-306-44972-7 / 9780306449727
Zustand	Neuware