Viral Oncology

Basic Science and Clinical Applications

Kamel Khalili, Kuan-Teh Jeang (Autoren)

Buch | Hardcover

496 Seiten

2010
Wiley-Blackwell (Verlag)
978-0-470-37991-2 (ISBN)

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Clinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernce allows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. The book contains 25 chapters covering basic and clinical aspects of viruses, including HPV, HBV, HCV, polyomaviruses, Kaposi’s associated viruses, retroviruses (including HIV-1 associated malignancies), and EBV. Several chapters are devoted to basic science of oncogenic viruses for the study of their pathogenesis, drug development, and employment of viral vectors for vaccine and gene therapy. Clinical materials are embedded within chapters, and there are also complementary, clinically based chapters describing natural courses and treatments.

Kamel Khalili, PhD, Professor and Chair, Department of Neuroscience, Temple University, and Kuan-Teh Jeang, MD, PhD, Head, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, NIH, are among the leading scientists in the field of human DNA and RNA viruses. Each of them has more than 25 years' experience in studying oncogenic viruses.

Foreword vii

Preface xi

Contributors xiii

1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1
Rachel A. Katzenellenbogen and Denise A. Galloway

2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23
Amy Baldwin and Karl Münger

3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57
Miranda Thomas, David Pim, and Lawrence Banks

4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89
Krzysztof Reiss, Kamel Khalili, and Luis Del Valle

5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113
C. Richard Boland, Luigi Ricciardiello, and Ajay Goel

6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129
Michael J. Imperiale and Dweepanita Das

7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149
Abhilasha V. Rathi and James M. Pipas

8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165
Janet S. Butel

9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191
Natalya Baranova and Michele Carbone

10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211
Timothy M. Block and Anand S. Mehta

11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225
Mei-Hwei Chang and Ding-Shinn Chen

12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243
Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun

13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267
Donna Sir and Jing-Hsiung James Ou

14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279
Masao Matsuoka

15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295
Susan J. Marriott

16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317
Melissa Agsalda and Bruce Shiramizu

17 HIV-RELATED LYMPHOMA 337
Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini

18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351
Veenu Minhas and Charles Wood

19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA 377
Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger

20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409
Joseph S. Pagano

21 EPSTEIN–BARR VIRUS AS A PATHOGEN 425
Wasim A. Dar and Bill Sugden

Index 453

Zusatzinfo	Photos: 75 B&W, 35 Color; Drawings: 50 B&W, 0 Color
Verlagsort	Hoboken
Sprache	englisch
Maße	163 x 242 mm
Gewicht	839 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	0-470-37991-X / 047037991X
ISBN-13	978-0-470-37991-2 / 9780470379912
Zustand	Neuware