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Methods for Structural Analysis of Protein Pharmaceuticals -

Methods for Structural Analysis of Protein Pharmaceuticals

Wim Jiskoot, Daan Crommelin (Herausgeber)

Buch | Hardcover
678 Seiten
2005 | 2005 ed.
AAPS Press (Verlag)
978-0-9711767-2-0 (ISBN)
CHF 349,95 inkl. MwSt
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Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. In the coming years, the patents on a number of the first-generation protein pharmaceuticals will expire, opening the door for the development of biogenerics into the market. However, it is very difficult to characterize these compounds so that the results can be replicated in a generic form. This volume details the nature of the different analytical techniques and how they are relevant for characterizing pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that can be monitored during production and over time. It also will be useful for students, fellows, and research scientists who are working in the academic world and in the pharmaceutical/biotechnology industry on basic aspects of proteins.

Ultraviolet Absorption Spectroscopy.- Pluorescence Spectroscopy.- Circular Dichroism Spectroscopy.- Fourier Transform Infrared Spectroscopy.- Raman Spectroscopy.- Nuclear Magnetic Resonance Spectroscopy.- Light Scattering.- Liquid Chromatography.- Capillary Electrophoresis.- Analytical Ultracentrifugation.- Field-Flow Fractionation.- Mass Spectrometery: Protein Conformational Analysus and Molecular Recognition.- Mass Spectrometry: Proteomics.- Immunoassays.- Surface Plasmon Resonance.- Microarray-Based Methods.- Calorimetry.- Atomic Force Microscopy.- Molecular Modeling.- Concluding Remarks: Analytical Methods of Protein Formulations.

Erscheint lt. Verlag 5.12.2005
Reihe/Serie Biotechnology: Pharmaceutical Aspects ; III
Zusatzinfo 183 Illustrations, black and white; X, 678 p. 183 illus.
Verlagsort Arlington, VA
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pflege
Medizin / Pharmazie Pharmazie PTA / PKA
ISBN-10 0-9711767-2-8 / 0971176728
ISBN-13 978-0-9711767-2-0 / 9780971176720
Zustand Neuware
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