Drug Metabolism and Pharmacokinetics
2024
IntechOpen (Hersteller)
978-0-85014-148-1 (ISBN)
IntechOpen (Hersteller)
978-0-85014-148-1 (ISBN)
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This book, and #60;i and #62;Drug Metabolism and Pharmacokinetics and #60;/i and #62;, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and
metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in
pharmacokinetic, metabolomic, and bioanalytical studies. and #60;br and #62;
Key Features: and #60;br and #62;
• Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety
evaluations and #60;br and #62;
• Depicts experimental and biophysical techniques used in bioanalytical and metabolomic
studies and #60;br and #62;
• Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug–
drug interactions, and toxicokinetics and #60;br and #62;
Written by a global team of experts, this book is a valuable resource for drug discovery scientists,
drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical
scientists, healthcare professionals, researchers, teaching faculty, and students.
metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in
pharmacokinetic, metabolomic, and bioanalytical studies. and #60;br and #62;
Key Features: and #60;br and #62;
• Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety
evaluations and #60;br and #62;
• Depicts experimental and biophysical techniques used in bioanalytical and metabolomic
studies and #60;br and #62;
• Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug–
drug interactions, and toxicokinetics and #60;br and #62;
Written by a global team of experts, this book is a valuable resource for drug discovery scientists,
drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical
scientists, healthcare professionals, researchers, teaching faculty, and students.
| Erscheint lt. Verlag | 14.2.2024 |
|---|---|
| Reihe/Serie | Pharmaceutical Science |
| Verlagsort | London |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| ISBN-10 | 0-85014-148-6 / 0850141486 |
| ISBN-13 | 978-0-85014-148-1 / 9780850141481 |
| Zustand | Neuware |
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