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From Morphological Imaging to Molecular Targeting

Implications to Preclinical Development

Markus Schwaiger, Ludger Dinkelborg, Hermann Schweinfurth (Herausgeber)

Buch | Hardcover

XIII, 196 Seiten

2004 | 2004
Springer Berlin (Verlag)
978-3-540-20137-3 (ISBN)

Lese- und Medienproben

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Because of the current progress in molecular medicine (genomics, proteomics), a plethora of new and often human-specific targets are being identified. These targets often play a significant role in the pathogenesis of diseases, and identifying them offers the potential for early diagnosis and intervention. An early in vivo validation of specific ligands binding to these targets in humans is needed to as sess their potential for targeted imaging and radiotherapy. Further- VI Preface more, such validation studies may allow for a better understanding of the molecular processes underlying phannacologic activity and therefore for a more successful development of phannaceuticals in general. The purpose of the Ernst Schering Research Foundation (ESRF) Workshop 48 was to provide a forum for an open exchange on the state of the art in the early development of such radiophanna ceuticals. Experts from academia, industry, and regulatory authori ties were invited to give presentations on aspects covering the identi fication of targets, preclinical studies on the safety of ligands, as well as their validation in human clinical trials. It was our intention to cover both the opportunities and the challenges that scientists in this field are facing. Radiopharmaceuticals are uniquely suitable for the above-men tioned target validation studies.

1 Molecular Imaging: Dream or Reality?.- 2 Target Discovery and Validation.- 3 Noninvasive Imaging in Drug Discovery and Development.- 4 Internal Dose Assessment - Extrapolation from Animal Species to the Human.- 5 PET for Drug Development.- 6 Future Directions in Molecular Imaging.- 7 Regulatory Implications - The EU Perspective.- 8 Nonclinical Development of Radiopharmaceuticals: Regulatory Considerations for the United States Food and Drug Administration.- 9 The Japanese Perspective on Radiopharmaceuticals.- Previous Volumes Published in This Series.

Erscheint lt. Verlag	16.6.2004
Reihe/Serie	Ernst Schering Foundation Symposium Proceedings
Zusatzinfo	XIII, 196 p. 19 illus., 7 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	127 x 203 mm
Gewicht	405 g
Themenwelt	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Nuklearmedizin
Schlagworte	clinical research • drug discovery • Molecular Imaging • Molecular Targeting • Nuklearmedizin • pharmacology • Positron Emission Tomography • Radiaton Oncology • Radiobilogy
ISBN-10	3-540-20137-8 / 3540201378
ISBN-13	978-3-540-20137-3 / 9783540201373
Zustand	Neuware