Torsades de Pointes

Buch | Softcover

376 Seiten

2022
Academic Press Inc (Verlag)
978-0-12-821446-6 (ISBN)

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Over the past 25-30 years, deaths due to Torsades de Pointes (TdP) have resulted in numerous drugs being withdrawn from the market. However, nearly 200 drugs that may prolong the QT interval and cause TdP remain available. A number of drugs with the potential to cause TdP are among the top 200 most prescribed drugs in the US, whilst new information regarding TdP is emerging rapidly. The purpose of this book is to provide a comprehensive source of information on the topic of torsades de pointes (TdP), which is a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG).

Torsades de Pointes provides a detailed, up-to-date and emerging information related to the epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management of the life-threatening polymorphic ventricular tachycardia, also known as torsades de pointes. The book contains current knowledge, incorporating recent and cutting-edge advances in understanding of topics including inherited channelopathies and congenital LQTS; drugs that cause QT interval prolongation and TdP; non-drug causes of acquired QT interval prolongation and TdP; epidemiology of inherited and acquired TdP; morbidity and mortality associated with TdP, particularly in association with specific antimicrobials, antidepressants and antipsychotics, and methadone; cellular and molecular mechanisms of TdP, traditional and emerging risk factors for TdP; methods of prevention and risk reduction for TdP; and clinical management of patients with TdP.

This book is an essential reference for both clinicians and researchers – providing guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area.

Prof. Tisdale is a Professor of Pharmacy at Purdue University and an Adjunct Professor under the School of Medicine at Indiana University. His main research focus is studying drugs that cause torsades de pointes (TdP) and methods of prevention and reducing the risk of drug-induced TdP. He has published more than 100 journal articles and book chapters, with an emphasis on the topic of drug-induced QT interval prolongation and TdP. He is also a fellow of the American Heart Association, the American College of Clinical Pharmacy, the American Pharmacists Association, and the National Academies of Practice.

1. Overview of torsades de pointes 2. Torsades de pointes associated with inherited channelopathies 3. Drug-induced torsades de pointes 4. Mechanisms of torsades de pointes 5. Traditional risk factors for QT interval prolongation and torsades de pointes 6. Emerging risk factors for QT interval prolongation and torsades de pointes 7. Predictive analytics for reducing the risk of QT interval prolongation and torsades de pointes 8. Antiarrhythmic agents and torsades de pointes 9. Psychotropic agents and torsades de pointes 10. Antimicrobial agents and torsades de pointes 11. Methadone, synthetic opioids and torsades de pointes 12. Torsades de pointes in patients with cancer 13. Strategies for prevention and management of QT interval prolongation and torsades de pointes 14. Important unanswered research questions related to torsades de pointes

Erscheinungsdatum	17.03.2022
Zusatzinfo	100 illustrations (50 in full color); Illustrations
Verlagsort	San Diego
Sprache	englisch
Maße	216 x 276 mm
Gewicht	1020 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	0-12-821446-5 / 0128214465
ISBN-13	978-0-12-821446-6 / 9780128214466
Zustand	Neuware