The Kidney Hypertension in Diabetes Mellitus
Kluwer Academic Publishers (Verlag)
978-0-7923-2829-2 (ISBN)
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The sum of clinical problems caused by diabetic renal disease has been steadily increasing since the first edition of this book was published in 1988. The years since have seen significant progress in research activities - including improvement in the treatment programmes to prevent end-stage renal failure. It has become clear that the diabetic kidney is extremely pressure-sensitive, responding to effective antihypertensive treatment by retarded progression of disease. Some agents may be more beneficial in this respect than others, although effective blood-pressure reduction, per se, is crucial throughout the stages of diabetic renal disease. However, the prime cause of diabetic renal disease is related to poor metabolic control and it is now documented that good metabolic control is able to postpone, or perhaps even prevent, the development of renal disease. However, in many individuals we are not able to provide such a quality of control that will prevent complications, and therefore non-glycaemic intervention remains important. Much information is now available on the exact mechanisms behind poor metabolic control and development of renal disease.
It is likely that a combination of genetic predisposition and metabolic and haemodynamic abnormalities explain the progression to renal disease, seen in about 30% of diabetic individuals. Much of this development probably relates to modifiable genetic factors, such as blood-pressure elevation or haemodynamic aberrations. However, mechanisms related to the response to hyperglycaemia are also of importance, as is the possibility that these metabolic or haemodynamic pathways may be inhibited. This volume reviews older data, as well as the progress seen within the research on diabetic nephropathy over the last five years, and describes the state of the art of development in this research.
Definition of diabetic renal disease in insulin-dependent diabetes mellitus based on renal function tests; C.E. Mogensen. Albuminuria and renal disease in NIDDM-patients; A. Schmitz. Familial factors in diaberic nephropathy; D.J. Pettitt, W.C. Knowler. Hypertension, cardiovascular disease, diabetes mellitus, and diabetic nephropathy: role of insulin resistance; A. Solini, R.A. Defronzo. Diabetes, hypertension, and kidney disease in the Pima Indians compared with other populations; W.C. Knowler, R.G. Nelson, D.J. Pettitt. Economic evaluations of strategies for preventing renal disease in non-insulin dependent diabetes mellitus; D.L. Manninen, E.J. Dabach, F.B. Dong, R.E. Aubert, S.M. Teutsch, W.H. Herman. Incidence of nephropathy in insulin-dependent diabetes mellitus as related to mortality and cost-benefit of early intervention; K. Borch-Johnsen. Measurement of albumin and other urinary proteins in low concentration in diabetes mellitus: techniques and clinical significance; D.J.F. Rowe, W. Gatling. Office tests for microalbuminuria; P.L. Poulsen. Risk factors for progression of microalbuminuria in relatively young NIDDM-patients; R. Kikkawa, M. Henada. The clinical course of renal disease in caucasian NIDDM-patients; S. Nielsen, A. Schmitz. Von Willebrand factor and the development of renal and vascular complications in diabetes; C.D.A. Stehouwer. Smoking and diabetic nephropathy; P.T. Sawicki. Light microscopy of diabetic glomerulopathy: the classic lesion; S. Olsen. Haematuria and diabetic nephropathy; P. Kincaid-Smith, J.A. Whitworth. Glomerular ultrastructural changes in microalbuminuric IDDM-patients; H.-J. Bangstad, R. Osterby. Understanding of diabetic nephropathy from kidney and pancreas transplantation; P. Fioretto, M. Mauer. Sodium-hydrogen antiport, cell function and susceptibility to diabetic nephropathy; R. Trevisan, G. Viberti. Biochemical aspects of diabetic nephropathy; E.D. Schleicher. The Steno hypothesis and glomerular basement membrane biochemistry in diabetic nephropathy; Kofoed-Enevoldsen. Volume homeostasis and blood pressure in diabetic states; J.A. O'Hare, J.B. Ferriss. Pathogenesis of diabetic glomerulopathy: the role of glomerular hemodynamic factors; J.P. Vora, S. Anderson, B.M. Brenner. Roles of growth factors in diabetic kidney disease; A. Flyvbjerg, B. Nielsen, C. Skjaeligrbaeligk, J. Frystyk, H. Grosnbaek, H.Orskov. Blood-pressure elevation in diabetes: results from 24-h ambulatory blood pressure.
| Sprache | englisch |
|---|---|
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Diabetologie |
| Medizinische Fachgebiete ► Innere Medizin ► Nephrologie | |
| ISBN-10 | 0-7923-2829-9 / 0792328299 |
| ISBN-13 | 978-0-7923-2829-2 / 9780792328292 |
| Zustand | Neuware |
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