Hereditary Breast Cancer

Claudine Isaacs, Timothy R. Rebbeck (Herausgeber)

Buch | Softcover

400 Seiten

2019
CRC Press (Verlag)
978-0-367-38862-1 (ISBN)

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This text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer, offering clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk.

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this
source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

Claudine Isaacs, Timothy R. Rebbeck

Introduction. OVERVIEW OF HEREDITARY BREAST CANCER. Genetic Epidemiology of Hereditary Breast Cancer. Breast Cancer Risk Estimation Models. Bioethics of Genetic Testing for Hereditary Breast Cancer. HBC SYNDROMES WITH KNOWN GENETIC ETIOLOGIES. Cancer Risks in BRCA1 and BRCA2 Mutation Carriers. Cowden's Syndrome. Li-Fraumeni Syndrome. Other Syndromes that Include Breast Cancer as a Component. Low penetrance genes. ASSESSMENT AND DISSEMINATION OF CLINICAL RISKS FOR BRCA1/2 MUTATION CARRIERS. Biology of BRCA1/2-associated Carcinogenesis. Genetic Testing and Counseling Issues. Molecular Diagnostics: Methods and Limitations. Cancer Risk Modifiers. BRCA1/2 in underserved or special populations. Psychological Impact of Genetic Testing. SCREENING AND PREVENTION OF HBC. Breast Cancer Screening and Prevention Options. Ovarian Cancer Screening and Prevention Options. Management of mutation-negative women. CLINICAL MANAGEMENT OF HBC. Pathology of Breast Tumors in Hereditary Breast Cancer. Pathology of Ovarian Tumors in Mutation Carriers. Local treatment Issues in HBC. Breast Cancer in Mutation Carriers.Impact on Systemic Therapy.

Erscheinungsdatum	16.09.2019
Verlagsort	London
Sprache	englisch
Maße	178 x 254 mm
Gewicht	453 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
ISBN-10	0-367-38862-6 / 0367388626
ISBN-13	978-0-367-38862-1 / 9780367388621
Zustand	Neuware