Sickle Cell Disease and Hematopoietic Stem Cell Transplantation

Emily Riehm Meier, Allistair Abraham, Ross M. Fasano (Herausgeber)

Buch | Softcover

XIII, 334 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-87292-6 (ISBN)

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This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management.

Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.

Emily Riehm Meier, MD, MSHS Pediatric Hematologist and Director, Sickle Cell Research, Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA Allistair Abraham, MDChildren's National Medical Center, Division of Blood and Marrow Transplantation, Washington, DC, USA Ross M. Fasano, MDEmory University School of Medicine, Department of Pathology & Laboratory Medicine, Atlanta GA, USA

Clinical Manifestations of Sickle Cell Disease Across the Lifespan.- Pathobiology of Sickle Cell Disease Vaso-Occlusion and Targeted Therapies.- Current Non-HSCT Related Treatments for SCD.- Risk Based Therapies for Sickle Cell Disease.- Transfusion Support of the Patient with Sickle Cell Disease Undergoing Transplantation.- Neurological Manifestations of Sickle Cell Disease and Their Impact on Allogeneic Hematopoietic Stem Cell Transplantation.- Overview of Hematopoietic Stem Cell Transplantation for Non-Malignant Diseases.- Unique Challenges of Hematopoietic Stem Cell Transplant for Sickle Cell Disease.- The Ethics of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.- Psychosocial Care and Education of Children with Sickle Cell Disease undergoing Hematopoietic Stem Cell Transplant and their Families.- Long Term Effects of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.- Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.- Unrelated Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.- Haploidentical Hematopoietic Cell Transplantation for Sickle Cell Disease.- Gene Therapy 101: The Path Toward Becoming a Realistic Cure for Patients with Sickle Cell Disease.

"An authoritative work on hematopoietic stem cell transplantation (HSCT) ... . Written by leading expert clinicians and researchers ... . this is a very valuable resource for clinicians and scientists dealing with this devastating disease and pursuing a curative therapy." (Ravi Salgia, Doody's Book Reviews, August, 2018)

“An authoritative work on hematopoietic stem cell transplantation (HSCT) … . Written by leading expert clinicians and researchers … . this is a very valuable resource for clinicians and scientists dealing with this devastating disease and pursuing a curative therapy.” (Ravi Salgia, Doody's Book Reviews, August, 2018)

Erscheint lt. Verlag	18.8.2018
Zusatzinfo	XIII, 334 p. 21 illus., 16 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	718 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
Schlagworte	GVHD prophylaxis • hydroxyurea • molecular phenotyping • reduced intensity conditioning • silent cerebral infarcts • transfusional hemochromatosis
ISBN-10	3-319-87292-3 / 3319872923
ISBN-13	978-3-319-87292-6 / 9783319872926
Zustand	Neuware