Personalised Medicine

Lessons from Neurodegeneration to Cancer

Buch | Softcover

VIII, 260 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-86922-3 (ISBN)

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The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.

Preface - Personalised Medicine: Lessons from Neurodegenration to Cancer, Sherif F. El-Khamisy.- chap. 1 Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair, Dean T. Williams et al.- chap. 2 Nucleotide excision repair: from neurodegeneration to cancer, Liakos et al.- chap. 3 The Role of Protein-Linked DNA Breaks in Personalized Medicine Walaa R. et al.- chap. 4 The Emerging Role of Proteomics in Precision Medicine: Application in Neurodegenerative Diseases and Neurotrauma, Rana Alaaeddineet al.- chap. 5 The Role of Nitric Oxide from Neurological Disease to Cancer, Ahmed Maher et al.- chap. 6 RNA nuclear export: from neurological disorders to cancer, Guillaume M. Hautbergue.- chap. 7. Can astrocytes be a target for precision medicine, Chloe Allen et al.- chap. 8 Mitochondrial Diseases as Model of Neurodegeneration, Laila A. Selim et al.- chap. 9 Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a ModelOrganism, Arwa A. Abugableet al.- chap. 10 The Power of Zebrafish in Personalised Medicine, Sarah Baxendale et al.- chap. 11 Alzheimer's Disease: a Modular Approach Based on GSK-3beta Inhibitors Reem k. Arafa et al.- chap. 12. Regenerative medicine: advances from developmental to degenerative diseases, Nicholas F. Blairet al.- chap. 13 Gene therapy in the nervous system: failures and successes, Jayanth S. Chandran et al.- index.

Erscheint lt. Verlag	18.8.2018
Reihe/Serie	Advances in Experimental Medicine and Biology
Zusatzinfo	VIII, 260 p. 98 illus., 52 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	178 x 254 mm
Gewicht	700 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Schlagworte	Cancer • Degenerative disorders • DNA repair • Genome Instability • Personalised Medicine
ISBN-10	3-319-86922-1 / 3319869221
ISBN-13	978-3-319-86922-3 / 9783319869223
Zustand	Neuware