Regulatory Genes of AdpA Subfamily in Streptomyces: Function and Evolution

Biology of AdpA Regulators in Streptomyces

Bohdan Ostash (Autor)

Buch | Softcover

67 Seiten

2018
De Gruyter Open (Verlag)
978-3-11-062776-3 (ISBN)

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AdpA is a regulatory protein of the AraC/XylS type which was first identified in 1993 as an activator of streptomycin production by Streptomyces griseus. Today streptomycete genomes are known to invariably harbor gene adpA, which is important for processes as diverse as replication and transcriptional control of genes for morphogenesis, antibiotic biosynthesis, and polymer decomposition to name just a few. Extreme pleiotropicity of adpA gene and its functional location at the nexus of morphological and physiological differentiation in Streptomyces fueled numerous investigations of this fascinating group of regulators, in a broad set of species. This monograph is an attempt to put together all existing information about functions of AdpA proteins in the context of biological processes it orchestrates. Special attention is paid to the description of suggested and experimentally proven cases of AdpA involvement in regulation of antibiotic production. This aspect of AdpA biology might be of great interest for current efforts to discover novel antibiotics, which are desperately needed to counter the threat of multidrug resistant bacterial infections. Possible scenarios of origin and ongoing evolution of adpA orthologous group in Streptomyces conclude this monograph. ABSTRACTING & INDEXING Regulatory Genes of AdpA Subfamily in Streptomyces: Function and Evolution is covered by the following services: Baidu ScholarBarnes & NobleBayerische StaatsbibliothekBDSBoDBowker Book DataCiandoCNKI Scholar (China National Knowledge Infrastructure)DimensionsEBSCOElsevier - Scopus BooksExLibrisGoogle BooksGoogle ScholarNavigaReadCubeSemantic ScholarTDOne (TDNet)WorldCat (OCLC)X-MOLAdditionally, the proceedings volume is registered and indexed in the Crossref database and accessible on Amazon.

lt;p>Bohdan Ostash

Erscheinungsdatum	02.09.2018
Zusatzinfo	35 col. ill., 1 col. tbl.
Verlagsort	Warschau/Berlin
Sprache	englisch
Maße	210 x 280 mm
Gewicht	462 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie
Schlagworte	AdpA • Antibiotics • AraC/XylS type regulators • Biologie • Biotechnology • Genetics • Genetics & Genomics • grammar • Life Sciences • Medical • Morphogenesis • PLMI13 • Prince • Science • Stories • Streptomyces • Streptomyces, antibiotics, AdpA, AraC/XylS type re • Streptomyces, antibiotics, AdpA, AraC/XylS type regulators, transcriptional factors, morphogenesis • transcriptional factors
ISBN-10	3-11-062776-0 / 3110627760
ISBN-13	978-3-11-062776-3 / 9783110627763
Zustand	Neuware