Handbook of Eicosanoids (1987)

Volume I, Part A

A. L. Willis (Autor)

Buch | Softcover

326 Seiten

2019
CRC Press (Verlag)
978-1-138-55947-9 (ISBN)

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Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.

A. L. Willis

Section 1: INTRODUCTION TO THE AREA. 1.Therapeutic Promise of the Eicosanoid Area: An Overview. Section 2: INHIBITORS OF EICOSANOID PRODUCTION. 1.Antiphospholipase Proteins: Introduction and Overview. 2. Effects of Corticosteroids on Release of Eicosanoid Precursors. 3. Drugs that Inhibit the Activities or Activation of Phospholipases and Other Acylhydrolases. 4. Cyclooxygenase Inhibitors. 5. Lipoxygenase Inhibitors. 6. Selective Inhibitors of Thromboxane Synthetase. Section 3: MODULATORS OF EICOSANOID ACTIONS. 1. Classification of Prostanoid Receptors. 2. Eicosanoid Receptor Antagonists.3. Leukotriene Antagonists. 4.Regulation of Cyclic Nucleotide Metabolism in Human Platelets by Prostanoids. 5. Opposite Effects of Prostaglandins on Human Platelets Mediated by Distinct Protein Kinases. Index.

Erscheinungsdatum	12.01.2019
Reihe/Serie	CRC Press Revivals
Verlagsort	London
Sprache	englisch
Maße	178 x 254 mm
Gewicht	453 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-138-55947-4 / 1138559474
ISBN-13	978-1-138-55947-9 / 9781138559479
Zustand	Neuware