Etiology and Morphogenesis of Congenital Heart Disease (eBook)

From Gene Function and Cellular Interaction to Morphology

H.Scott Baldwin, Bradley B. Keller, Roger R. Markwald, Toshio Nakanishi, Deepak Srivastava, Hiroyuki Yamagishi (Herausgeber)

eBook Download: EPUB

2016 | 1st ed. 2016
XII, 383 Seiten
Springer Japan (Verlag)
978-4-431-54628-3 (ISBN)

Infos

This volume focuses on the etiology and morphogenesis of congenitalheart diseases. It reviews in detail the early development and differentiation ofthe heart, and later morphologic events of the cardiovascular system, coveringa wide range of topics such as gene functions, growth factors, transcriptionfactors and cellular interactions that are implicated in cardiac morphogenesisand congenital heart disease. This book also presents recent advances in stemcell and cell sheet tissue engineering technologies which have the potential toprovide novel in vitro disease models and to generate regenerative paradigmsfor cardiac repair and regeneration.   Thisis the ideal resource for physician scientists and investigators looking forupdates on recent investigations on the origins of congenital heart disease andpotential future therapies.

Inhalt

Part
I. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now
and Future .- Reprogramming Approaches to
Cardiovascular Disease: From Developmental Biology to Regenerative Medicine.- The arterial epicardium, a developmental approach to cardiac disease
and repair.- Cell sheet tissue engineering for heart failure.- Future treatment of heart failure and pathophysiological analysis of
various heart diseases using human iPS cell-derived cardiomyocytes.- Congenital heart disease: in search of remedial etiologies.- Part II. Left-Right Axis and
Heterotaxy Syndrome.- Left-right
Asymmetry and Human Heterotaxy Syndrome.- Roles of motile
and immotile cilia in left-right symmetry breaking.- Role of cilia
and left-right patterning in congenital heart disease.- Pulmonary
arterial hypertension in patients with heterotaxy /polysplenia syndrome.- Part III. Cardiomyocyte and Myocardial
Development.- Single Cell Expression Analyses of
Embryonic Cardiac Progenitor Cells.- Meis1 Regulates Post-Natal Cardiomyocyte
Cell Cycle Arrest.- Intercellular signalling in cardiac development and
disease: NOTCH.- The epicardium in ventricular septation during evolution
and development.- S1P-S1p2 signaling in cardiac precursor cells migration.- Myogenic progenitor cell differentiation is dependent on modulation of
mitochondrial biogenesis through autophagy.- The role of the
thyroid in the developing heart.-
Part IV. Valve Development and Diseases.- Atrioventricular valve abnormalities: From molecular mechanisms
underlying morphogenesis to clinical perspective.- Molecular
Mechanisms of Heart Valve Development and Disease.- A novel role for
endocardium in perinatal valve development: Lessons learned from tissue
specific gene deletion of the Tie1 receptor tyrosine kinase.- The Role of the Epicardium in the Formation of the Cardiac Valves in
the Mouse.- TMEM100, a novel intracellular transmembrane protein
essential for vascular development and cardiac morphogenesis.- Cell autonomous regulation of BMP-2 in endocardial cushion cells during
AV valvuloseptal morphogenesis.-
Part V. The Second Heart Field and Outflow Tract.- Properties of cardiac progenitor cells in the second heart field.- Nodal signaling and congenital heart defects.- Utilizing
Zebrafish to Understand Second Heart Field Development.- A history and
interaction of outflow progenitor cells implicated in “Takao syndrome”.- The loss of Foxc2 expression in the outflow tract links the interrupted
arch in the conditional Foxc2 knockout mouse.- Environmental
modification for phenotype of truncus arteriosus in Tbx1 hypomorphic mice.- Part VI. Vascular Development and
Diseases.- Extracellular matrix remodeling in
vascular development and disease.- The “cardiac neural crest” concept
revisited.- Roles of endothelial Hrt genes for vascular development.- Placental Expression of Type 1 and 3 Inositol Trisphosphate Receptors
is Required for the Extra-embryonic Vascular Development.- Tissue Remodeling in Vascular Wall in Kawasaki Disease-related
Vasculitis Model Mice.- Part
VII. Ductus Arteriosus.- Progerin
expression during normal closure of the human ductus arteriosus: A case of
premature ageing?.- The multiple roles of prostaglandin E2 in the regulation of
the ductus arteriosus.- Developmental Differences in the Maturation of Sarcoplasmic
Reticulum and Contractile Proteins in Large Blood Vessels Influences Their
Contractility.- Fetal and Neonatal Ductus Arteriosus is Regulated with
ATP-sensitive Potassium Channel.-
Part VIII. Conduction System and Arrhythmia.- Regulation of vertebrate conduction system development.- Cardiac Pacemaker Development from a Tertiary Heart Field.- Endothelin receptor type A expressing cell population in the inflow
tract contributes to chamber formation.- Specific isolation of HCN4 positive
cardiac pace-making cells derived from embryonic stem cell.- Part IX. Current Molecular Mechanism
in Cardiovascular Development.- Combinatorial
functions of transcription factors and epigenetic factors in heart development
and disease.- Pcgf5 contributes to PRC1 (Polycomb repressive complex 1)
in developing cardiac cells.-
non-coding RNAs in cardiovascular disease.- Part X. iPS Cells and Regeneration in
Congenital Heart Diseases.- Human
pluripotent stem cells to model congenital heart disease.- Engineered cardiac tissues generated from immature cardiac and
stem-cell derived cells: Multiple approaches and outcomes.- Dissecting the left heart hypoplasia by pluripotent stem cells.- Lentiviral gene transfer to iPS cells; toward the cardiomyocyte
differentiation of Pompe disease-specific iPS cells.- Molecular
analysis of long-term cultured cardiac stem cells for cardiac regeneration.- Epicardial contribution in neonatal heart regeneration.- Part XI. Current Genetics in
Congenital Heart Diseases.- Genetic
discovery for congenital heart defects.- Evidence that deletion of ETS-1, a
gene in the Jacobsen syndrome (11q-) cardiac critical region, causes congenital
heart defects through impaired cardiac neural crest cell function.- Notch signaling in aortic valve development and disease.- To detect and explore mechanism of CITED2 mutation and methylation in
children with congenital heart disease.

Produkt-Details

• Erscheint lt. Verlag: 24.6.2016
• Verlagsort: Tokyo
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Schlagworte: Cardiac morphogenesis • cardiac morphology • Cellular Interaction • Cellular interactions • Congenital Heart Disease • Gene functions • Growth factors • iPS cells • transcription factors • Vascular Development
• ISBN-10: 4-431-54628-6 / 4431546286
• ISBN-13: 978-4-431-54628-3 / 9784431546283