Sickle Cell Disease and Hematopoietic Stem Cell Transplantation (eBook)

Emily Riehm Meier, Allistair Abraham, Ross M. Fasano (Herausgeber)

eBook Download: PDF

2017 | 1st ed. 2018
XIII, 334 Seiten
Springer International Publishing (Verlag)
978-3-319-62328-3 (ISBN)

Infos

This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD).  The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of  HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. 

Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.

Emily Riehm Meier, MD, MSHS

Pediatric Hematologist and Director, Sickle Cell Research, Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA

Allistair Abraham, MD

Children's National Medical Center, Division of Blood and Marrow Transplantation, Washington, DC, USA

Ross M. Fasano, MD

Emory University School of Medicine, Department of Pathology & Laboratory Medicine, Atlanta GA, USA

Inhalt

Part I Sickle Cell Disease   1. Clinical Manifestations of Sickle Cell Disease Across the Lifespan Lydia H. Pecker, Jane Little   2. Pathobiology of Sickle Cell Disease Vaso-Occlusion and Targeted Therapies Kerry A. Morrone, Jennifer Davila, W. Beau Mitchell, Deepa Manwani   3. Current Non-HSCT Related Treatments for SCD Claire L. Anderson, Deepika S. Darbari   4. Risk Based Therapies for Sickle Cell Disease Emily R. Meier   5. Transfusion Support of the Patient with Sickle Cell Disease Undergoing Transplantation Jeanne E. Hendrickson, Ross M. Fasano   6. Neurological Manifestations of Sickle Cell Disease and Their Impact on Allogeneic Hematopoietic Stem Cell Transplantation Jessica Carpenter, Monica L. Hulbert   Part II Hematopoietic  Stem Cell Transplantation   7. Overview of Hematopoietic Stem Cell Transplantation for Non-Malignant Diseases Karen L Zimowski, Shanmuganathan Chandrakasan   8. Unique Challenges of Hematopoietic Stem Cell Transplant for Sickle Cell Disease Pooja Khandelwal, Michael Grimley   9. The Ethics of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease Robert Sheppard Nickel, Naynesh Kamani   10. Psychosocial Care and Education of Children with Sickle Cell Disease undergoing Hematopoietic Stem Cell Transplant and their Families Steven J. Hardy, Jasmine Holt, Amanda L. Thompson   11. Long Term Effects of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease Karim T. Sadak, Angela R. Smith, Monica Bhatia   12. Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease Gregory M.T. Guilcher, John T. Horan   13. Unrelated Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease Alexander Ngwube, Shalini Shenoy   14. Haploidentical Hematopoietic Cell Transplantation for Sickle Cell Disease Elizabeth O. Stenger, Allistair Abraham15. Gene Therapy 101: The Path Toward Becoming a Realistic Cure for Patients with Sickle Cell Disease Alexis Leonard, Allistair Abraham

Produkt-Details

• Erscheint lt. Verlag: 19.9.2017
• Zusatzinfo: XIII, 334 p. 21 illus., 16 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Schlagworte: GVHD prophylaxis • hydroxyurea • molecular phenotyping • reduced intensity conditioning • silent cerebral infarcts • transfusional hemochromatosis
• ISBN-10: 3-319-62328-1 / 3319623281
• ISBN-13: 978-3-319-62328-3 / 9783319623283