The Blood-Brain Barrier in Health and Disease
Seiten
2016
Morgan & Claypool Publishers (Verlag)
978-1-61504-739-0 (ISBN)
Morgan & Claypool Publishers (Verlag)
978-1-61504-739-0 (ISBN)
The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.
The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.
The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.
Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota LSU Health Sciences, Shreveport University of Mississippi Medical Center, Jackson
Introduction
Characteristics of the Blood-Brain Barrier
Ultrastructural Components of the Blood-Brain Barrier
Cellular Components of the Blood-Brain Barrier
Compromising the Blood-Brain Barrier
Summary
References
About the Authors
| Erscheinungsdatum | 06.01.2017 |
|---|---|
| Reihe/Serie | Colloquium Series on Integrated Systems Physiology: From Molecule to Function |
| Mitarbeit |
Herausgeber (Serie): D. Neil Granger Ph.D., Joey P. Granger Ph.D. |
| Verlagsort | San Rafael |
| Sprache | englisch |
| Maße | 191 x 235 mm |
| Gewicht | 525 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| ISBN-10 | 1-61504-739-5 / 1615047395 |
| ISBN-13 | 978-1-61504-739-0 / 9781615047390 |
| Zustand | Neuware |
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