Dermal Absorption and Toxicity Assessment
Marcel Dekker Inc (Verlag)
978-0-8247-0154-3 (ISBN)
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This volume examines the dermal absoption process with emphasis on determining the toxicity arising from exposure to pharmaceuticals, cosmetics, and other substances. It serves as a bench resource for scientists seeking effective and timesaving means of estimating risk. Contributors also reveal how environmental hazards such as metal compounds, contaminated soil and water, and sun sensitivity occur and are measured through the skin. Practical information is provided on specific products, from analgesics and anti-inflammatory drugs, to perfumes, sunscreens and hair dyes.
The relationship between structure and barrier function of skin; dermal metabolism; systemic toxicity in man secondary to percutaneous absorption. Part 1 Modelling of dermal risk assessment: occupational skin disease - a case study; current issues in the in vitro measurement of percutaneous absorption; investigation of the skin permeation in vitro; prediction -physiological models; prediction - simple risk models and overview of dermal risk assessment; cutaneous microdialysis for human in vivo dermal absorption studies; physicochemical determinants of stratum corneum permeation. Part 2 Pharmeceuticals: in vitro/in vivo correlations in transdermal drug delivery; irritancy of topical chemicals and transdermal delivery systems; chemical penetration enhancement - possibilities and problems; drugs used for skin diseases; drugs for pain and inflammation; site of effects; iontophoresis; topical therapeutic agents used in wound care. Part 3 Cosmetics: regulation of cosmetics in the United States; experimental design considerations and use of in vitro skin penetration data in cosmetic risk assessment; percutaneous absorption of hair dyes; sunscreens - toxicological aspects; exposure to fragrances - their absorption and potential toxicity. Part 4 Environmental: dermal absorption and toxicity assessment; human skin penetration by metal compounds; soil contamination -theoretical descriptions; percutaneous absorption of hazardous substances from soil and water; bathing water - percutaneous absorption of water contaminants; ultrastructural effects of some solvents and vehicles on the stratum corneum and other skin components - evidence for an extended mosaic-partitioning model of the skin barrier.
| Erscheint lt. Verlag | 23.6.1998 |
|---|---|
| Reihe/Serie | Drugs and the Pharmaceutical Sciences |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 1383 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
| ISBN-10 | 0-8247-0154-2 / 0824701542 |
| ISBN-13 | 978-0-8247-0154-3 / 9780824701543 |
| Zustand | Neuware |
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