Pain Versus Man
Lippincott Williams and Wilkins (Verlag)
978-0-88167-857-4 (ISBN)
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This volume is devoted to the most challenging type of pain encountered in clinical practice - pain that is due, not to an identifiable noxious stimulus, but to a dysfunction of the nociceptive system, i.e. an organic, functional, or pharmacologically induced disturbance of the neural machinery responsible for pain transmission and control. Leading international investigators examine the functions and dysfunctions of the neural mechanisms involved in nociception and present new insights into the pathophysiology, clinical features, and therapy of pain syndromes resulting from disturbances in these mechanisms, such as phantom limb pain, other deafferentation pain syndromes, idiopathic migraine and cluster headaches, primary fibromyalgia, and central panalgia.
Part 1 Nociception - from physiology to pathology - basic aspects: evolution of the concept of pain; the biological function and dysfunction of different pain mechanisms; deafferentation pain and the opioids in the dorsal horn of the rat spinal cord; the wide spectrum of functions of capsaicin-sensitive nociceptive afferents; action of antibiotics in two animal models of pain; physiological factors influence substance-P evoked flare in human skin; capsaicin-sensitive afferents and pain arising from the urinary bladder; physiological analgesia is obtainable by potentiating presynaptic mechanisms involved in central pain control. Part 2 Clinical profiles: profiles of CNS neuropeptides in chronic pain of different nature; referred pain from viscera - when the symptom persists despite the extinction of the visceral focus; pathophysiological mechanisms operating in reflex sympathetic dystrophy; when cardiac pain offends somatic structures - shoulder-hand syndrome; fibromyalgia - a dysfunctional syndrome with chronic pain; central panalgia as an expression of systemic analgodeficiency. Part 3 Functional and organic damages from deafferentation: man versus pain - the dilemma of morphine; mechanisms of compulsive self-directed behaviour by humans and subhumans from deafferentations; phantom pain and phenomena after amputations; ascending modulation of thalamic function and pain - experimental and clinical data; changes in vasomation and nociception in trigeminal deafferented humans; involvement of opioid and non-opioid peptides in deafferentation pain. Part 4 Idiopathic cephalic pain: painless and painful sensations anatomofunctionally characterize viscerogenic and somatogenic headache; the possible role of serotonin in the migraine syndrome; trigeminal pain mechanisms in cluster headache; EEG alterations in migraine - an expression of pain hypertransmission?; pain and sex steroids; sympathetic and sensory pupillary impairment in cluster headache - a fortuitous or related coexistence?; focus on latent nociceptive dysfunction in humans; studies on phantom toothache; lymphocyte beta-endorphin immunoreactivity in migraine patients - effects of chlorimipramine treatment.
| Erscheint lt. Verlag | 1.12.1991 |
|---|---|
| Reihe/Serie | Advances in Pain Research and Therapy ; v. 20 |
| Zusatzinfo | 40 tables, 2 half-tones, 68 line drawings |
| Verlagsort | Philadelphia |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 620 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Schmerztherapie | |
| ISBN-10 | 0-88167-857-0 / 0881678570 |
| ISBN-13 | 978-0-88167-857-4 / 9780881678574 |
| Zustand | Neuware |
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