Glycocalyx & its Roles in Inflammation & Atherosclerosis

Ye Zeng (Autor)

Buch | Softcover

125 Seiten

2016
Nova Science Publishers Inc (Verlag)
978-1-63485-825-0 (ISBN)

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The major component of glycocalyx, heparan sulfate covalently attaches to proteoglycan core proteins, which is abundant at the cell surface and in the extracellular matrix. Heparan sulfate could provide binding sites on endothelial cells to retain and activate highly diffusible cytokines and inflammatory chemokines to regulate cell functions, such as proliferation and migration. Under physiological and pathological conditions, the remodeling in structure of heparan sulfate including the abnormal expression, and irregular distribution that critically play a fundamental role in inflammation and atherosclerosis, as well as many other diseases was observed. This book aims to integrate a current understanding of the identified molecular mechanisms in the regulation of glycocalyx, especially the heparan sulfate structure. Additionally, the available drugs that can protect the heparan sulfate or induce its synthesis, and the measurement techniques of the endothelial glycocalyx, as well as the relationship between structure and function of heparan sulfate in the progression of inflammation and atherosclerosis are analysed.

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Erscheinungsdatum	03.12.2016
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	204 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-63485-825-5 / 1634858255
ISBN-13	978-1-63485-825-0 / 9781634858250
Zustand	Neuware