Alpha-1 Antitrypsin

Role in Health and Disease

Adam Wanner, Robert A. Sandhaus (Herausgeber)

Buch | Hardcover

X, 173 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-23448-9 (ISBN)

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This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children and is associated with chronic obstructive lung disease in adults. While it is a rare condition, the mechanisms underlying the clinical manifestations of this deficiency have been largely clarified. Treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases. It concludes with a discussion of rare disorders linked to alpha-1 antitrypsin deficiency and the role of healthcare organizations in the treatment of these diseases. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.

Adam Wanner, MDDivision of Pulmonary and Critical Care MedicineMiller School of MedicineUniversity of Miami Miami, FL, USARobert A. Sandhaus, MD, PhDDivision of Pulmonary, Critical Care, and Sleep MedicineNational Jewish HealthDenver, CO, USA

Alpha-1- Antitrypsin and the Serpins.- Alpha-1 Antitrypsin: The protein.- Misfolding and Polymerisation of Alpha 1 -Antitrypsin - Conformational Pathology and Therapeutic Targeting.- Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency.- United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency.- Lung Disease of Alpha-1 Antitrypsin Deficiency.- Alpha-1-Antitrypsin Deficiency: Role in Health and Disease.- Alpha-1 Antitrypsin as a Therapeutic Agents for Conditions not Associated with Alpha-1 Antitrypsin Deficiency.- The Alpha-1 Constellation of Voluntary Health Organizations as a Paradigm for Confronting Other Rare Diseases.

Erscheint lt. Verlag	6.1.2016
Reihe/Serie	Respiratory Medicine
Zusatzinfo	X, 173 p. 27 illus., 12 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
Schlagworte	Genetic Mutations • liver disease • lung disease • Medicine • Pneumology/Respiratory System • Protein Misfolding • Rare Diseases • Serpins
ISBN-10	3-319-23448-X / 331923448X
ISBN-13	978-3-319-23448-9 / 9783319234489
Zustand	Neuware