Molecular Aspects of Hematologic Malignancies
Springer Berlin (Verlag)
978-3-642-44522-4 (ISBN)
This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors' own laboratories.
'Part I MOLECULAR BIOLOGY OF SELECTED HEMATO-ONCOLOGIC DISEASES
1. Molecular biology of acute lymphoblastic leukemia
Malgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich, and Tomasz Szczepanski
2. Genetic mechanisms and molecular markers of neoplastic transformation in acute myeloid leukemia
Agata A. Filip, Marta Libura, Sebastian Giebel, and Olga Haus
3. Molecular pathogenesis of aggressive B-cell lymphomas
Przemyslaw Juszczynski and Krzysztof Warzocha
4. Molecular biology and classification of multiple myeloma
Anna Dmoszynska and Norbert Grzasko
5. Chronic lymphocytic leukemia
Anton W. Langerak and Yorick Sandberg
6. The molecular biology of chronic myeloid leukemia
Tomasz Sacha, Kajetana Foryciarz, and Aleksander B. Skotnicki
7. Molecular biology of myelodysplastic syndromes
Francesc Solé
8. Myeloproliferative neoplasms
Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner, and Aleksandra Leszczynska
Part II DIAGNOSTICS AND MONITORING OF THERAPY OF HEMATO-ONCOLOGIC DISEASES
9. Flow cytometric immunophenotyping as diagnostic tool of hematopoietic malignancies
Lukasz S_dek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena, Julia Almeida, Alberto Orfao, and Tomasz Szczepanski
10. Cytogenetics in hematology
Olga Haus, Anna Poluha, and Katarzyna Skonieczka
11. Monitoring of minimal residual disease in acute lymphoblastic leukemia
Tomasz Szczepanski, Malgorzata Dawidowska, and Katarzyna Derwich
12. Gene expression profiling in hematologic malignancies
Przemyslaw Juszczynski, Bjoern Chapuy, Malgorzata Szczepaniak, and Krzysztof Warzocha
Part III MOLECULAR PROCEDURES INVOLVED IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
13. Allogeneic transplantation of hematopoietic stem cells
Jacek Wachowiak
14. Genetic basis of donor-recipient matching in allogeneic transplantation
of hematopoietic stem cells
Jacek Nowak and Jacek Wachowiak
15. Chimerism following allogeneic transplantation of hematopoietic stem cells
Malgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak, and
Michal Witt
16. Peritransplantation monitoring of minimal residual disease in acute lymphoblastic leukemia
Malgorzata Dawidowska, Katarzyna Derwich, and Tomasz Szczepanski
17. Biobanks of cellular material
Wieslaw Wiktor-Jedrzejczak and Elzbieta Urbanowska
Part IV MOLECULAR DIAGNOSTIC PROTOCOLS
18. Biobanking of cellular material
Anna Poluha and El_bieta Urbanowska
19. Isolation of mononuclear cells from human blood and bone marrow by density gradient centrifugation
Malgorzata Dawidowska
20. Molecular techniques commonly used in hematooncolology
Monika D. Kraszewska and Ewa Zi_tkiewicz
21. Genetic methods of HLA typing
Jacek Nowak, Renata Mika-Witkowska, and El_bieta Graczyk-Pol
22. Post-transplant chimerism analysis through STR-PCR and RQ-PCR
Malgorzata Dawidowska, Katarzyna Guz, Agnieszka Orzinska, Justyna Smolarczyk-Wodzynska, Monika D. Kraszewska, and Michal Witt
23. Analysis of minimal residual disease with the use of rearrangements of Ig/TCR genes
through RQ-PCR
M. Dawidowska, Vincent H. J. van der Velden, Michal Witt, and Tomasz Szczepanski
24. Molecular diagnostics of acute myeloblastic leukemia
Marta Libura, Agata A. Filip, and Olga Haus
25. Assessment of the presence and the level of BCR-ABL fusion gene expression and mutational status in ABL kinase domain.
Sylwia Czekalska, Magdalena Zawada, and Izabela Florek
26. Studies of rearrangements and somatic hypermutation of IGHV genes in chronic lymphocytic leukemia
Anton W. Langerak, Richard Rosenquist, Paolo Ghia, Chrysoula Belessi, Kostas Stamatopoulos, and Frederic Davi for the ERIC-IgCLL group
27. Molecular biology methods in the diagnosis of multiple myeloma
Anna Dmoszynska and Sylwia Chocholska
28. Molecular methods in myeloproliferative neoplasms
Aleksandra Leszczynska, Witold Prejzner, Maria Bieniaszewska, and
From the reviews:
"This book describes current diagnostic tools and clinical procedures used for hematological malignancies. ... The goal was to meet the needs of both clinical hematologists who treat patients with leukemia, lymphoma, and/or multiple myeloma and those who study these diseases in the laboratory. ... an excellent review of molecular biology for specific hematological malignancies and disorders. It also covers important molecular testing techniques that are commonly used in the diagnosis, management, and surveillance of these malignancies. ... a valuable addition to any hematologist's library." (John Patrick Galvin, Doody's Review Service, October, 2012)| Erscheint lt. Verlag | 26.6.2015 |
|---|---|
| Reihe/Serie | Principles and Practice |
| Zusatzinfo | X, 476 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Studium |
| Schlagworte | Hematology • leukemia • minimal residual disease • Molecular Biology • Oncology • stem cell transplantation |
| ISBN-10 | 3-642-44522-5 / 3642445225 |
| ISBN-13 | 978-3-642-44522-4 / 9783642445224 |
| Zustand | Neuware |
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