Transcriptional Control of Lineage Differentiation in Immune Cells (eBook)

Wilfried Ellmeier, Ichiro Taniuchi (Herausgeber)

eBook Download: PDF

2014 | 2014
VIII, 331 Seiten
Springer International Publishing (Verlag)
978-3-319-07395-8 (ISBN)

Infos

Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.

Wilfried Ellmeier, PhD., is Professor of Immunology at the Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna, Austria. Taniuchi Ichiro, M.D. PhD. Professor is Group Director of the Laboratory for Transcriptional Regulation RIKEN Research Center for Allergy and Immunology (RCAI), Japan.

Inhalt

Genetic and epigenetic control of early lymphocyte developmentTomokatsu Ikawa The role of BTB-zinc finger transcription factors during T cell development and in the regulation of T cell-mediated immunityWilfried Ellmeier and Ichiro Taniuchi Transcriptional control of the development and function of Vα14i NKT cellsIsaac Engel and Mitchell Kronenberg Transcriptional Control of Regulatory T cellsMichael Delacher, Lisa Schreiber, David D. Richards, Carla Farah, Markus Feuerer, Jochen Huehn Transcriptional regulatory networks for CD4 T cell differentiationDarah Christie and Jinfang Zhu Transcriptional control of NK cell differentiation and functionVictoria Male and Hugh J.M. Brady Transcriptional control of pre-B cell development and leukemia preventionSwee Heng Milon Pang, Sebastian Carotta and Stephen L Nutt Transcription factors controlling innate lymphoid cell fate decisionsChristoph S.N. Klose and Andreas Diefenbach Transcriptional control of dendritic cell differentiationIzumi Sasaki, Tsuneyasu Kaisho Helper T cell plasticity: Impact of Extrinsic and Intrinsic Signals On Transcriptomes and EpigenomesMichael Bonelli, Han-Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno and John J. O’Shea

Produkt-Details

• Erscheint lt. Verlag: 2.9.2014
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: VIII, 331 p.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Studium
• Schlagworte: adaptive immunity • Cell fate specification • Immune cell differentiation • Innate Immunity • Llineage plasticity • Transcription factor networks
• ISBN-10: 3-319-07395-8 / 3319073958
• ISBN-13: 978-3-319-07395-8 / 9783319073958