Natural Products and Cancer Drug Discovery

Buch | Softcover

244 Seiten

2014
Springer-Verlag New York Inc.
978-1-4899-9565-0 (ISBN)

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With reliable commentary and analysis in a sector often associated with outlandish claims, this volume provides a valuable overview of how natural products could generate new cancer therapeutics as well as mitigating the deleterious effects of chemotherapy.

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Preface.- The Impact of Natural Products upon Cancer Chemotherapy.- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth.- Discodermolide: Past, Present and Future.- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents .- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates.- Natural Product Scaffolds in Cancer Therapy.- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery.- Accessing Anti-Cancer Natural Products by Plant Cell Culture.- Natural Products as Tools for Discovering New Cancer Targets.- Index.

Reihe/Serie	Cancer Drug Discovery and Development
Zusatzinfo	XII, 244 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium
Schlagworte	Cancer Therapeutics • discodermolide • HDAC inhibitors • natural product cytotoxins • Natural Products and Cancer Drug Discovery
ISBN-10	1-4899-9565-X / 148999565X
ISBN-13	978-1-4899-9565-0 / 9781489995650
Zustand	Neuware