Ir Genes

Past, Present, and Future

Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Benjamin D. Schwartz, Donald C. Shreffler (Autoren)

Buch | Softcover

622 Seiten

2011
Humana Press Inc. (Verlag)
978-1-4612-5635-9 (ISBN)

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The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

Genetic Organization of I-Region Genes.- Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products.- Ir Gene Function: Cellular Site(s) and Mechanism(s) of Action.- The Role of Ia Antigens in Restricted Cell Interactions.- Lessons on Ir Genes Derived from T Cell Clones and T Cell Hybridomas.- Where From Here?.

Erscheint lt. Verlag	4.11.2011
Reihe/Serie	Experimental Biology and Medicine ; 4
Zusatzinfo	XXVI, 622 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	1-4612-5635-6 / 1461256356
ISBN-13	978-1-4612-5635-9 / 9781461256359
Zustand	Neuware