Relaxin and the Fine Structure of Proteins

Christian Schwabe, Erika E. Büllesbach (Autoren)

Buch | Softcover

XI, 200 Seiten

2013 | 1. Softcover reprint of the original 1st ed. 1998
Springer Berlin (Verlag)
978-3-662-12911-1 (ISBN)

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Relaxin, perhaps more than any other hormone, has a varied history of eliciting enthusiasm, rejection, skepticism, and long lapses of neglect. Long after its discovery, it was a hormone in search of a physiological role in humans. Today, relaxin is implicated in mammary growth, development and function, ionotropic and chronotropic action on the heart, and angiogenic activity in both the peripheral tissues and the endometrium. It is best known for its effect on the uterus and the symphysis pubis in preparation for parturition. However, the literature suggests that not all functions occur in one species. This book describes how to obtain the necessary molecules or derivatives for research, reaching right into the design of new molecules for specific applications.

1. Introduction.- 2. A Very Brief History.- 3. The Relaxin Insulin-Like Motif in Protein Structures.- 4. Other Mammalian and Chondrichtian Relaxins.- 5. Isolation and Sequence Analysis of Porcine Relaxin.- 6. The Initial Approach to Receptor-Binding Site Studies.- 7. The N-Terminal Region of the Relaxin A Chain.- 8. The Total Synthesis of Human Relaxin.- 9. Analytic of the Prototype.- 10. The Receptor-Binding Site of Relaxin.- 11. Merely a G (Glycine).- 12. The Development of Insulaxin, The First True "Zwitterhormon".- 13. A Surprising Message from Murines.- 14. The Mouse, a Very Small Rat, a Very Big Mistake.- 15. Retro-D-Relaxin.- 16. The Relaxin-Like Factor.- 17. The Relaxin Receptor.- 18. Relaxin as a Drug.- 19. Relaxin and Genealogy.- Color Figures.

Erscheint lt. Verlag	6.1.2013
Zusatzinfo	XI, 200 p. 112 illus., 21 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	338 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Cell • Cell Culture • endocrines • Endokrine • growth • Hormone • insulin-like • Protein • Proteine • proteins • Protein Structure • receptor • Relaxin • synthesis • tissue • Zellkultur, tierische
ISBN-10	3-662-12911-6 / 3662129116
ISBN-13	978-3-662-12911-1 / 9783662129111
Zustand	Neuware