Sjögren’s Syndrome

Clinical and Immunological Aspects

Norman Talal, Haralampos M. Moutsopoulos, Stuart S. Kassan (Herausgeber)

Buch | Softcover

XVI, 300 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 1987
Springer Berlin (Verlag)
978-3-642-50120-3 (ISBN)

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I have been a student of Sjogren's syndrome for virtually all of my professional life. My education in this disease began in 1962 when I arrived at the National Institutes of Health to begin a Clinical Asso ciateship with Dr. Joseph J. Bunim. Bunim introduced me to a pat ient with Sjogren's syndrome of 8 years duration who had devel oped malignant lymphoma 6 months previously. He told me that there were other such patients. I obtained serum samples from these patients and studied them by the then new technique of immuno electrophoresis. We observed that an initial hypergammaglobulin emia could progressively decline to hypogammaglobulinemia with loss of autoantibodies. One patient in this initial series had macrog lobulinemia. We published this report and suggested that the auto immunity predisposed to the malignant transformation. Thus began my love affair with this disease. In those days many rheumatologists considered Sjogren's syn drome simply a variant of rheumatoid arthritis. It's curious that two decades ago there was little confusion between Sjogren's syndrome and systemic lupus erythematosus, whereas today there is great con fusion. There is still a great need for internationally agreed upon di agnostic criteria, which merely illustrates once again the difficulty of accurate diagnosis in our profession. The multidisciplinary aspects of Sjogren's syndrome require au thorities in several areas of medicine. The various chapter contribu tors are experts in their field and have often put aside other respon sibilities to complete their contributions and not delay publication.

I. Introduction.- 1. Historical Perspective: The Early Years (1930-1960).- 2. The Patient's Perspective.- II. Clinical Spectrum.- A. Glandular Findings.- 1. Oral Manifestations of Sjögren's Syndrome.- 2. The Eye in Sjögren's Syndrome.- 3. Chemistry of Saliva.- 4. Histopathology of Sjögren's Syndrome.- B. Extraglandular Findings.- 1. Primary Sjögren's Syndrome in the People's Republic of China.- 2. Neuromuscular Complications of Primary Sjögren's Syndrome.- 3. The Respiratory System in Sjögren's Syndrome.- 4. Gastrointestinal and Hepatobiliary Features in Sjögren's Syndrome.- 5. Renal Disease with Sjögren's Syndrome.- 6. Inflammatory Vascular Disease in Sjögren's Syndrome.- C. Lymphoid Malignancy.- 1. Lymphoid Malignancy and Monoclonal Proteins.- 2. Detection of Lymphoma in Sjögren's Syndrome by Analysis of Immunoglobulin Gene Rearrangements.- 3. Lymphoproliferative Disorders in Japanese Patients with Sjögren's Syndrome.- D. Relationship to Other Autoimmune Diseases.- 1. Relationship of Sjögren's Syndrome to Rheumatoid Arthritis.- 2. Sjögren's Syndrome with Systemic Lupus Erythematosus/Mixed Connective Tissue Disease.- 3. Sjögren's Syndrome and Systemic Sclerosis (Scleroderma).- E. Diagnosis and Differential Diagnosis.- 1. Diagnosis and Differential Diagnosis of Sjögren's Syndrome.- III. Laboratory Abnormalities.- 1. Rheumatoid Factor in Sjögren's Syndrome.- 2. Autoantibodies in Sjögren's Syndrome.- 3. Immunogenetics of Sjögren's Syndrome.- 4. The Relationship Between Anti-RO(SS-A) Precipitin Antibody Positive Sjögren's Syndrome and Anti-RO(SS-A) Precipitin Antibody Positive Lupus Erythematosus.- 5. Immunologic Abnormalities in Sjögren's Syndrome.- 6. Animal Models of Sjögren's Syndrome.- IV. Treatmentof Sjögren's Syndrome.

Erscheint lt. Verlag	19.5.2012
Zusatzinfo	XVI, 300 p. 68 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	547 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Antibody • autoimmune disease • Diagnosis • Diseases • Genetics • Health • immunity • Immunoglobulin • Lymphoma • Medicine • Pathology • patients • proteins • Rheumatoid Arthritis • Systemic Lupus Erythematosus
ISBN-10	3-642-50120-6 / 3642501206
ISBN-13	978-3-642-50120-3 / 9783642501203
Zustand	Neuware