Database Annotation in Molecular Biology (eBook)

Principles and Practice

Arthur M. Lesk (Herausgeber)

eBook Download: PDF

2005 | 1. Auflage
266 Seiten
John Wiley & Sons (Verlag)
978-0-470-85685-7 (ISBN)

Infos

Two factors dominate current molecular biology: the amount of raw
data is increasing very rapidly and successful applications in
biomedical research require carefully curated and annotated
databases. The quality of the experimental data -- especially
nucleic acid sequences -- is satisfactory; however, annotations
depend on features inferred from the data rather than measured
directly, for instance the identification of genes in genome
sequences. It is essential that these inferences are as accurate as
possible and this requires human intervention.

With the recognition of the importance of accurate database
annotation and the requirement for individuals with particular
constellations of skills to carry it out, annotators are emerging
as specialists within the profession of bioinformatics. This book
compiles information about annotation -- its current status, what
is required to improve it, what skills must be brought to bear on
database curation and hence what is the proper training for
annotators.

The book should be essential reading for all people working on
biological databases, both biologists and computer scientists. It
will also be of interest to all users of such databases, including
molecular biologists, geneticists, protein chemists, clinicians and
drug developers.

Autor

Arthur M. Lesk, The Pennsylvania State University, U.S.A.

Inhalt

Preface.

List of Contributors.

1. Annotation and Databases: Status and Prospects (M.
Hoebeke, H. Chiapello, J.-F. Gibrat, Ph. Bessieres and J.
Garnier).

I: THE DATABANKS.

2. Survey of Sequence Databases: Archival Projects (M.
Magrane, M. Garcia-Pastor and R. Apweiler).

3. Survey of Sequence Databases: Derived Databases (M.
Pruess, N. Mulder and R. Apweiler).

4. Databanks of Macromolecular Structure (H.J. Bernstein
and F.C. Bernstein).

5. Gene Expression Databases (H. Parkinson).

II: THE BASIS OF ANNOTATION.

6. Taxonomy: a Moving Target for Sequence Data (M.I.
Krichevsky).

7. Genomics and Proteomics: Design and Sources of
Annotation (K. Mayer and G. Mannhaupt).

8. Annotation of Protein Sequences (W.C. Barker and C.H.
Wu).

9. Issues in the Annotation of Protein Structures (G.J.
Swaminathan, J. Tate, R. Newman, A. Hussain, J. Ionides, K. Henrick
and S. Velankar).

10. Classification of Protein Function (A.M. Lesk, H.
Parkinson and J.C. Whisstock).

III: DATABASE DESIGN AND INTEGRATION.

11. Information Flow and Data Integration of Databanks
(C.H. Wu and W.C. Barker).

12. Models of Database Interconnectivity
(G.J.L.Kemp).

13. The European Bioinformatics Institute Macromolecular
Structure Relational Database Technology (H. Boutselakis, D.
Dimitriopoulos, K. Henrick, J. Ionides, M. John, P.A. Keller, P.
McNeil, J. Pineda and A. Suarez-Uruena).

IV: CONCLUSIONS AND PROSPECTS.

14. Looking Around, Looking Ahead (A.M. Lesk).

Index.

Produkt-Details

• Erscheint lt. Verlag: 1.9.2005
• Sprache: englisch
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Schlagworte: Bioinformatics & Computational Biology • Bioinformatik • Bioinformatik u. Computersimulationen in der Biowissenschaften • Biowissenschaften • Life Sciences • Molekularbiologie
• ISBN-10: 0-470-85685-8 / 0470856858
• ISBN-13: 978-0-470-85685-7 / 9780470856857