Nanotoxicity (eBook)

From In Vivo and In Vitro Models to Health Risks

Daniel A. Casciano, Saura C. Sahu (Herausgeber)

eBook Download: PDF

2009 | 1. Auflage
630 Seiten
Wiley (Verlag)
978-0-470-74779-7 (ISBN)

Infos

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as nanotoxicity the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessment nanotoxicity assessment by gene expression analysis in vivo and in vitro models for nanotoxicity testing mechanisms of nanotoxicity pharmakokinetics of nanomaterials nanotoxicity of foods including food processing, food packaging and food safety nanotoxicity of drugs including drug development and drug delivery nanotoxicity of cosmetics and consumer products health and environmental impact of nanotoxicity safety evaluation of nanomaterials regulatory impact of nanomaterials Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Autor

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007), and Toxicogenomics (Wiley, Oct 2008). Professor Daniel A. Casciano, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Professor Casciano was former director of the US Food and Drug Administration's National Center for Toxicological Research in Jefferson, Arkansas, USA.

Inhalt

Preface.

List of Contributors.

Acknowledgments.

1 Characterization of Nanomaterials for Toxicological Evaluation(Kevin W. Powers, Maria Palazuelos, Scott C. Brown and StephenM. Roberts).

2 Criteria and Implementation of Physical and ChemicalCharacteristics of Nanomaterials for Human Health Effects andEcological Toxicity Studies (Christie M. Sayes and David B.Warheit).

3 Considerations for the Design of Toxicity Studies of InhaledNanomedicines (Lea Ann Dailey).

4 High Aspect Ratio Nanoparticles and the Fibre PathogenicityParadigm (Craig A. Poland, Rodger Duffin and KenDonaldson).

5 Application of Zinc Oxide Quantum Dots in Food Safety (TonyJin, Dazhi Sun, Howard Zhang and Hung-Jue Sue).

6 Evaluation of Nanotoxicity of Foods and Drugs: BiologicalProperties of Red Elemental Selenium at Nano Size (Nano-Se) InVitro and In Vivo (Jinsong Zhang).

7 Evaluation of Toxicity of Nanostructures in Biological Systems(Adam J. Gormley and Hamidreza Ghandehari).

8 Developing Bioassay Methods for Evaluating Pulmonary Hazardsfrom Nanoscale or Fine Quartz/Titanium Dioxide ParticulateMaterials (David B. Warheit, Kenneth L. Reed and Christie M.Sayes).

9 Nanoparticles: Is Neurotoxicity a Concern? (Jianyong Wang,Wenjun Sun and Syed F. Ali).

10 Hepatotoxic Potential of Nanomaterials (Saura C.Sahu).

11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials onPlatelets (Jan Simak).

12 Sources, Fate and Effects of Engineered Nanomaterials in theAquatic Environment (David S. Barber, Nancy D. Denslow, R.Joseph Griffitt and Christopher J. Martyniuk).

13 Nanotoxicity of Metal Oxide Nanoparticles inVivo (Weiyue Feng, Bing Wang and Yuliang Zhao).

14 In Vivo Hypersensitive Pulmonary Disease Models forNanotoxicity (Ken-ichiro Inoue and Hirohisa Takano).

15 In Vivo and In Vitro Models for NanotoxicologyTesting (Rosalba Gornati, Elena Papis, Mario Di Gioacchino,Enrico Sabbioni, Isabella Dalle Donne, Aldo Milzani and GiovanniBernardini).

16 In Vitro and In Vivo Toxicity Study ofNanoparticles (Jayoung Jeong, Wan-Seob Cho, Seung Hee Kim andMyung-Haing Cho).

17 In Vitro and In Vivo Models for NanotoxicityTesting (Kyung O. Yu, Laura K. Braydich-Stolle, David M. Mattie,John J. Schlager and Saber M. Hussain).

18 In Vitro Models for Nanotoxicity Testing (YinfaMa).

19 In Vitro Human Lung Cell Culture Models to Study theToxic Potential of Nanoparticles (Fabian Blank, Peter Gehr andBarbara Rothen-Rutishauser).

20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence andMechanisms (Thomas R. Pisanic, Sungho Jin and Veronica I.Shubayev).

21 Toxicity Testing and Evaluation of Nanoparticles: Challengesin Risk Assessment (David Y. Lai and Philip G. Sayre).

22 Evaluating Strategies For Risk Assessment of Nanomaterials(Nastassja Lewinski, Huiguang Zhu and Rebekah Drezek).

23 Strategies for Risk Assessment of Nanomaterials (Hae-SeongYoon, Hyun-Kyung Kim, Dong Deuk Jang and Myung-Haing Cho).

24 Metal Nanoparticle Health Risk Assessment (Mario DiGioacchino, Nicola Verna, Rosalba Gornati, Enrico Sabbioni andGiovanni Bernardini).

25 Application of Toxicology Studies in Assessing the HealthRisks of Nanomaterials in Consumer Products (J.S. Tsuji, F.S.Mowat, S. Donthu and M. Reitman).

26 Safety Assessment of Engineered Nanomaterials in Direct FoodAdditives and Food Contact Materials (Penelope A. Rice, KimberlyS. Cassidy, Jeremy Mihalov and T. Scott Thurmond).

Index.

Rezensionen

"I can certainly envisage this book being used widely. Indeed, an
excellent and most timely book, clearly written, and sensitively
related to nano; above all, it really 'speaks' to the realities of
nanotoxicity. An additional bonus.....an important one at that....
Is .the list of references cited at the end of every contribution
that must make the acquisition of the volume urgent and
imperative." (Current Engineering Practice, 2010)

Produkt-Details

• Erscheint lt. Verlag: 4.8.2009
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Biochemie • Chemie • Chemistry • Nanomaterial • Nanomaterialien • nanomaterials • Nanostrukturiertes Material • Nanotechnologie • nanotechnology • Toxicology • Toxikologie
• ISBN-10: 0-470-74779-X / 047074779X
• ISBN-13: 978-0-470-74779-7 / 9780470747797