Immunosuppression Under Trial
Kluwer Academic Publishers (Verlag)
978-0-7923-5804-6 (ISBN)
Immunosuppression in solid organ transplantation is experiencing a worldwide revival since new drugs are now available in the late-1990s and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analyzed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.
Part 1 Setting the stages in clinical trials: Current results as reference for future improvements in immunosuppression, G. Opelz, et al; Rationale of clinical trials from the physician, C. Legendre; Minimal standards for reporting clinical trial results in transplantation, B.L. Kasiske, H. Chakkera; Methodological approach of clinical trials for renal transplantation, P. Landais, J.P. Jais. Part 2 Is acute rejection an appropriate surrogate marker?: Surrogate endpoints for clinical trials in renal transplantation, B.L. Kasiske; Is acute rejection an appropriate surrogate marker for clinical trials in liver transplantation? O. Farges; The success of clinical immunosuppressive trials in heart transplantation - the early detection of acute rejection, M. Antoine. Part 3 Towards long-term end-points: Factors influencing long-term allograft survival, C. Van Buren. Part 4 Can we minimize the long-term side-effects?: Patients' appraisal of side-effects in quality of life assessments of immunosuppressive regimens, P. Moons, et al; Cardiovascular complications after renal transplantation, V. Schwenger, et al; Strategies to minimize nephrotoxicity associated with calcineurin inhibitors, J. Alsina; Diabetogenic effect of immunosuppressive drugs, X. Martin; Can we minimize long-term side effects of immunosuppressive drugs on lipid metabolism? Z.A. Massy; Can we minimize the long-term side-effects of immunosuppressive drugs in pediatric patients? B. Tonshoff, et al. Part 5 Strategies: Induction therapy, D. Abramowicz, K.M. Wissing; Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence - randomised comparison of two cyclosporin regimens, J. Dantal, et al; Immunosuppression in composite tissue transplantation, J.-M. Dubernard, et al; The search for immunosuppressive synergy, C. Van Buren; Economic analysis of immunosuppression in transplantation - a review of recent studies in liver and kidney transplantation, J. Hutton. Part 6 Clinical trials for at-risk situations; Questions raised by the exclusion of "at risk" conditions from current trials in organ transplantation, J.P. Revillard, et al.
| Erscheint lt. Verlag | 31.5.1999 |
|---|---|
| Reihe/Serie | Transplantation and Clinical Immunology ; v. 31 |
| Zusatzinfo | Illustrations |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 450 g |
| Einbandart | gebunden |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie |
| Medizinische Fachgebiete ► Innere Medizin ► Nephrologie | |
| ISBN-10 | 0-7923-5804-X / 079235804X |
| ISBN-13 | 978-0-7923-5804-6 / 9780792358046 |
| Zustand | Neuware |
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