Signaling Mechanisms in Protozoa and Invertebrates

Buch | Softcover

XIII, 212 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1996
Springer Berlin (Verlag)
978-3-642-80108-2 (ISBN)

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Comparative endocrinology helps to find the roots of homeostatic regulation in organisms. In this context, many years ago a series of experiments were done, which demonstrated the hormonal regula tion also on the invertebrate level. The mechanisms are partly similar, partly different, from those found in vertebrates. The new receptor era of mammalian endocrinology stimulated research on invertebrate hormone receptors, and sophisticated methods are applied also to determine hormones. The experiments demonstrated the existence and even similar function of these structures and signaling molecules. However, data on hormones and receptors at the lowest level of metazoan life and the highest level of protozoan life were not at our disposal. About two decades ago, first observations on the presence of hormone receptors reacting to vertebrate hormones in protozoa were made. Since the early 1980s we know that hormone-like molecules similar to those of higher vertebrates are present also in unicellular organisms. The presence of some second messengers in Tetrahymena was recognized. Since then, the research has been extended and many structures - previously believed to be solely vertebrate characteristics, such as opiate receptors, similar to mammalian ones - were found in unicellular organisms. These observations justified the assumption of a complete endocrine system at protozoan level, where - considering the unicellularit- this seemed to be not required. However, it became clear that the roots of endocrine communication date back at least 2 billion years.

Evolutionary Significance of the Hormone Recognition Capacity in Unicellular Organisms. Development of Hormone Receptors.- 1 Introduction.- 2 Receptor Memory: Hormonal Imprinting.- 3 Problems of the Specificity of Imprinting.- 4 Time, Concentration, and Downregulation.- 5 Sugars of the Receptors.- 6 Cell Aging and Imprinting.- 7 Imprinting by Amino Acids and Oligopeptides.- 8 Receptors of the Nuclear Envelope.- 9 Possible Mechanisms of Imprinting.- 10 The Other Component: Hormones in Protozoa.- 11 Evolutionary Conclusions Based on the Unicellular Model.- References.- Studies on the Opioid Mechanism in Tetrahymena.- 1 Introduction to Opioid Mechanisms.- 2 The Opioid Mechanism in Tetrahymena.- 3 Conclusions.- References.- Adenylate and Guanylate Cyclases in Tetrahymena.- 1 Introduction.- 2 Cyclic Nucleotide Metabolism in Tetrahymena.- 3 Cyclases Involved in Cell Metabolism and Functions.- 4 Regulatory Mechanisms of Cyclases.- 5 Structure and Intracellular Distribution of Calmodulin.- 6 Conclusion.- References.- Signal Peptide-Induced Sensory Behavior in Free Ciliates: Bioassays and Cellular Mechanisms.- 1 Introduction.- 2 Peptide Signals in Ciliates.- 3 Bioassays Measuring Peptide-Induced Changes of Cell Behavior and Ciliary Activity.- 4 Cellular Mechanisms Related to Peptide Action on Individual Cell Behavior.- 5 Concluding Remarks.- References.- Ciliate Pheromones.- 1 Introduction.- 2 Background.- 3 Pheromone Notation and Origin.- 4 Pheromone Secretion and Purification.- 5 Pheromone Structure.- 6 Pheromone Genes.- 7 Pheromone Receptors.- 8 Competitive Pheromone Receptor-Binding Reactions.- 9 Pheromones as Growth Factors.- 10 Concluding Remarks.- References.- Cell-Surface GPI Expression in Protozoa. The Connection with the PI System.- 1 Introduction.- 2 The Cell-SurfaceExpression of GPI-Anchored Proteins in the Protozoa.- 3 Inositol Phospholipids in Tetrahymena pyriformis. The Possible Link Between the PI System and Synthesis of GPI.- References.- Cell Adhesion Proteins in the Nonvertebrate Eukaryotes.- 1 Introduction.- 1.1 History and Philosophy.- 1.2 Evolution.- 2 Approaches and Findings.- 3 Protista.- 4 Higher Eukaryotes.- 5 An Alveolate: Plasmodium.- 6 Plants.- 7 Fungi.- 8 Metazoa.- 9 Conclusions.- 10 Characteristics of Cell Adhesion Proteins.- 11 Extracellular Matrix Interactions.- 12 Role of Lectins and Carbohydrates.- 13 Signal Transduction and Cytoplasmic Domains.- References.- Animal Lectins as Cell Surface Receptors: Current Status for Invertebrate Species.- 1 Introduction.- 2 Animal Lectins as Cell Membrane Receptors.- 3 Lectin Families in Invertebrate and Protochordate Species. Their Association with the Hemocyte Plasma Membrane.- 4 Summary and Prospects.- References.- Characterization of the Receptor Protein-Tyrosine Kinase Gene from the Marine Sponge Geodia cydonium.- 1 Introduction.- 2 Protein Kinases.- 3 Receptor Protein-Tyrosine Kinases.- 4 Receptor Protein-Tyrosine Kinase from the Sponge Geodia cydonium.- 5 Proposed Function of the Sponge Receptor Protein-Tyrosine Kinase.- 6 Implication for Molecular Evolution of Metazoa.- 7 Summary and Perspectives.- References.

Erscheint lt. Verlag	23.12.2011
Reihe/Serie	Progress in Molecular and Subcellular Biology
Zusatzinfo	XIII, 212 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	358 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Biology • Development • endocrinology • Endokrinologie • Evolution • Invertebrates • Molecular Biology • Molekularbiogie • Physiologie • Physiology • Protozoa • receptor • receptors • Rezeptoren • Toology
ISBN-10	3-642-80108-0 / 3642801080
ISBN-13	978-3-642-80108-2 / 9783642801082
Zustand	Neuware