Chronic Hepatitis C Virus (eBook)

Advances in Treatment, Promise for the Future

Mitchell L. Shiffman (Herausgeber)

eBook Download: PDF

2011 | 2012
XVI, 332 Seiten
Springer New York (Verlag)
978-1-4614-1192-5 (ISBN)

Infos

Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Mitchell L.  Shiffman, MD
Liver Institute of Virginia, Bon Secours Health System, Richmond, VA, USA

Inhalt

Section I: Natural History of Chronic HCV Ch. 1- Epidemiology of Chronic HCV            Gary Davis            Ch. 2- Acute HCV                  Katja Deterding            Heiner Wedemeyer            Michael P. Manns Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis            Xavier Forns Ch. 4- Chronic HCV and Steatosis            Dawn McDowell Torres            Stephen A. Harrison Ch. 5- Chronic HCV and Hepatocellular Carcinoma            Morris Sherman Ch. 6- Extrahepatic Manifestations of Chronic HCV            Antonio Craxi            Vincenza Calvaruso Ch. 7- Chronic HCV and HIV Co-infection              Patrick Ingiliz            Maud Lemoine            Yves Benhamou Ch. 8- Chronic HCV in Patients with Renal Disease            Paul Martin            Fabrizio Fabrizi Ch. 9- Does Treatment Alter the Natural History of Chronic HCV            Bruce Bacon            Fasiha Kanwal Section II: Treatment of Chronic HCV with Interferon Based Therapy Ch. 10- Treatment with Interferon and Ribavirin            Stuart Roberts            William Kemp Ch. 11- Immune Modulators and Other Agents            Edgar D. Charles            Ira M. Jacobson Ch. 12- Measuring HCV RNA and Assessing Virologic Response            Jean-Michel Pawlotsky            Ch. 13- Response Guided Therapy            Mitchell Shiffman Ch. 14- Managing the Side Effects of Therapy            Curtis Cooper Ch. 15- The Genetics of Virologic Response            Andrew J Muir            Alison B. Jazwinski Ch. 16- Maintenance Therapy with Peginterferon            Nezem Afdahl            Raza Malik  Section III: Anti-viral Therapy for Chronic HCV Ch. 17- Anti-viral Targets in HCV            Bernd Kronenberger            Stefan Zeuzem Ch. 18- Mutations and the Development of Anti-viral Resistance            Geoffrey Dusheiko            Anna Maria Geretti Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy            Patrick Marcellin            Nathalie Boyer            Tarik Asselah Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin            Ed Gane Ch. 21- Maintenance Therapy with Oral Anti-viral Agents            Donald M. Jensen            Andrew Aronsohn Section IV: Liver Transplantation for Chronic HCV Ch. 22- Natural History of Chronic HCV after Liver Transplantation                      Michael Charlton            Bart J. Veldt Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV            Robert Brown            Elizabeth C. Verna Ch. 24- Treating HCV Prior to Liver Transplantation            Greg Everson            Alvaro Martinez-Camacho            Brett E. Fortune Ch. 25- Treating HCV after Liver Transplantation            Sammy Saab            Michael Chang            Hubert Sung              Ch. 2- Acute HCV                  Katja Deterding            Heiner Wedemeyer            Michael P. Manns Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis            Xavier Forns Ch. 4- Chronic HCV and Steatosis            Dawn McDowell Torres            Stephen A. Harrison Ch. 5- Chronic HCV and Hepatocellular Carcinoma            Morris Sherman Ch. 6- Extrahepatic Manifestations of Chronic HCV            Antonio Craxi            Vincenza Calvaruso Ch. 7- Chronic HCV and HIV Co-infection              Patrick Ingiliz            Maud Lemoine            Yves Benhamou Ch. 8- Chronic HCV in Patients with Renal Disease            Paul Martin            Fabrizio Fabrizi Ch. 9- Does Treatment Alter the Natural History of Chronic HCV            Bruce Bacon            Fasiha Kanwal Section II: Treatment of Chronic HCV with Interferon Based Therapy Ch. 10- Treatment with Interferon and Ribavirin            Stuart Roberts            William Kemp Ch. 11- Immune Modulators and Other Agents            Edgar D. Charles            Ira M. Jacobson Ch. 12- Measuring HCV RNA and Assessing Virologic Response            Jean-Michel Pawlotsky            Ch. 13- Response Guided Therapy            Mitchell Shiffman Ch. 14- Managing the Side Effects of Therapy            Curtis Cooper Ch. 15- The Genetics of Virologic Response            Andrew J Muir            Alison B. Jazwinski Ch. 16- Maintenance Therapy with Peginterferon            Nezem Afdahl            Raza Malik  Section III: Anti-viral Therapy for Chronic HCV Ch. 17- Anti-viral Targets in HCV            Bernd Kronenberger            Stefan Zeuzem Ch. 18- Mutations and the Development of Anti-viral Resistance            Geoffrey Dusheiko            Anna Maria Geretti Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy            Patrick Marcellin            Nathalie Boyer            Tarik Asselah Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin            Ed Gane Ch. 21- Maintenance Therapy with Oral Anti-viral Agents            Donald M. Jensen            Andrew Aronsohn Section IV: Liver Transplantation for Chronic HCV Ch. 22- Natural History of Chronic HCV after Liver Transplantation                      Michael Charlton            Bart J. Veldt Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV            Robert Brown            Elizabeth C. Verna Ch. 24- Treating HCV Prior to Liver Transplantation            Greg Everson            Alvaro Martinez-Camacho            Brett E. Fortune Ch. 25- Treating HCV after Liver Transplantation            Sammy Saab            Michael Chang            Hubert Sung              Ch. 2- Acute HCV                  Katja Deterding            Heiner Wedemeyer            Michael P. Manns Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis            Xavier Forns Ch. 4- Chronic HCV and Steatosis            Dawn McDowell Torres            Stephen A. Harrison Ch. 5- Chronic HCV and Hepatocellular Carcinoma            Morris Sherman Ch. 6- Extrahepatic Manifestations of Chronic HCV            Antonio Craxi            Vincenza Calvaruso Ch. 7- Chronic HCV and HIV Co-infection              Patrick Ingiliz            Maud Lemoine            Yves Benhamou Ch. 8- Chronic HCV in Patients with Renal Disease            Paul Martin            Fabrizio Fabrizi Ch. 9- Does Treatment Alter the Natural History of Chronic HCV            Bruce Bacon            Fasiha Kanwal Section II: Treatment of Chronic HCV with Interferon Based Therapy Ch. 10- Treatment with Interferon and Ribavirin            Stuart Roberts            William Kemp Ch. 11- Immune Modulators and Other Agents            Edgar D. Charles            Ira M. Jacobson Ch. 12- Measuring HCV RNA and Assessing Virologic Response            Jean-Michel Pawlotsky            Ch. 13- Response Guided Therapy            Mitchell Shiffman Ch. 14- Managing the Side Effects of Therapy            Curtis Cooper Ch. 15- The Genetics of Virologic Response            Andrew J Muir            Alison B. Jazwinski Ch. 16- Maintenance Therapy with Peginterferon            Nezem Afdahl            Raza Malik  Section III: Anti-viral Therapy for Chronic HCV Ch. 17- Anti-viral Targets in HCV            Bernd Kronenberger            Stefan Zeuzem Ch. 18- Mutations and the Development of Anti-viral Resistance            Geoffrey Dusheiko            Anna Maria Geretti Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy            Patrick Marcellin            Nathalie Boyer            Tarik Asselah Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin            Ed Gane Ch. 21- Maintenance Therapy with Oral Anti-viral Agents            Donald M. Jensen            Andrew Aronsohn Section IV: Liver Transplantation for Chronic HCV Ch. 22- Natural History of Chronic HCV after Liver Transplantation                      Michael Charlton            Bart J. Veldt Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV            Robert Brown            Elizabeth C. Verna Ch. 24- Treating HCV Prior to Liver Transplantation            Greg Everson            Alvaro Martinez-Camacho            Brett E. Fortune Ch. 25- Treating HCV after Liver Transplantation            Sammy Saab            Michael Chang            Hubert Sung              

Produkt-Details

• Erscheint lt. Verlag: 17.11.2011
• Zusatzinfo: XVI, 332 p. 53 illus., 33 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
• Schlagworte: hepatology
• ISBN-10: 1-4614-1192-0 / 1461411920
• ISBN-13: 978-1-4614-1192-5 / 9781461411925