Fibrogenesis (eBook)
XVI, 216 Seiten
Springer US (Verlag)
978-0-387-26476-9 (ISBN)
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options.
The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options.The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.
CONTENTS 5
EDITOR 9
CONTRIBUTORS 9
PREFACE 13
ABBREVIATIONS 14
Tissue Scarring: Lessons from Wound Healing 15
Pathological Significance of Renal Expression of Proinflammatory Molecules 23
Oxidative Stress, Lipoproteins and Angiotensin II: The Unholy Triad in the Pathogenesis of Renal Fibrosis 41
Involvement of NF-KB in Renal Inflammation and Sclerosis 52
Low- Density Lipoprotein and Glomerulosclerosis 59
Molecular Developments in the Treatment of Renal Fibrosis 75
Myocardial Infarction and Cardiac Fibrogenesis 91
Cardiac Fibrosis and Aging 111
Matrix Remodeling and Atherosclerosis Effect of Age 118
Molecular and Cellular Aspects of Liver Fibrosis 132
Recent Therapeutic Developments in Hepatic Fibrosis 136
Reversibility of Liver Fibrosis: Role of Matrix Metalloproteinases 157
Can Manipulation of Apoptotic Cell Death Benefit Tissue Scarring? 174
Pulmonaiy Fibrogenesis: The Role of Apoptosis and Its Clinical Potentials 192
Silica-Induced Inflammatoiy Mediators and Pulmonary Fibrosis 213
INDEX 225
| Erscheint lt. Verlag | 6.3.2007 |
|---|---|
| Reihe/Serie | Medical Intelligence Unit | Medical Intelligence Unit |
| Zusatzinfo | XVI, 216 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Medizin / Pharmazie ► Studium | |
| Schlagworte | aging • cell death • Cytokine • inflammation • Protein • proteins • tissue • transcription |
| ISBN-10 | 0-387-26476-0 / 0387264760 |
| ISBN-13 | 978-0-387-26476-9 / 9780387264769 |
| Haben Sie eine Frage zum Produkt? |
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