Handbook of Drug Monitoring Methods (eBook)

Therapeutics and Drugs of Abuse

Amitava DasGupta (Herausgeber)

eBook Download: PDF

2007 | 2008
X, 446 Seiten
Humana Press (Verlag)
978-1-59745-031-7 (ISBN)

Infos

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

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In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today's practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume's first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Inhalt

Preface 5
Contents 7
Contributors 9
1 Introduction to Therapeutic Drug Monitoring 11
2 Monitoring Free Drug Concentration 50
3 Analytical Techniques for Measuring Concentrations of Therapeutic Drugs in Biological Fluids 75
4 The Pre-Analytical Phaseof Drug Testing 95
5 Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins, and System Factors on Therapeutic Drug Monitoring 105
6 Digoxin 118
7 Interferences with Measurement of Anticonvulsants 139
8 Pitfalls in Measuring Antidepressant Drugs 155
9 Immunosuppressive Drugs 170
10 Therapeutic Drug Monitoring in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome 205
11 Pharmacogenomics and Personalized Medicine 215
12 Interference of Heterophilic and Other Antibodies in Measurement of Therapeutic Drugs by Immunoassays 228
13 Drug--Herb and Drug--Food Interactions 237
14 Toxic Element Testing with Clinical Specimens 264
15 Alcohol Testing 284
16 Introduction to Drugs of Abuse Testing 297
17 Urinary Adulterants and Drugs of Abuse Testing 316
18 Hair, Oral Fluid, Sweat, and Meconium Testing for Drugs of Abuse 335
19 Abused and Designer Drugs and How They Escape Detection 363
20 Interpretation of Amphetamines Screening and Confirmation Testing 376
21 Clinical False-Positive Drug Test Results 391
22 Providing Expert Witness for Alcohol and Positive Drugs of Abuse Test Results 403
Index 417

Produkt-Details

• Erscheint lt. Verlag: 5.10.2007
• Zusatzinfo: X, 446 p. 44 illus.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Rechtsmedizin
• Schlagworte: Amphetamine • Detailed mechanisms • drugs of abuse • False negative • False positive • Forensic toxicology • Therapeutic drug monitoring
• ISBN-10: 1-59745-031-6 / 1597450316
• ISBN-13: 978-1-59745-031-7 / 9781597450317