Chitosan

Modifications & Applications in Dosage Form Design

Ashok Kumar Tiwary, Bharti Sapra, Gurpreet Kaur, VIKAS RANA (Autoren)

Buch | Softcover

110 Seiten

2012
Nova Science Publishers Inc (Verlag)
978-1-61761-174-2 (ISBN)

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Chitosan is the deacetylated form of chitin. Generally, the substance becomes soluble in dilute acids when the degree of deacetylation is more than 50%. The solubility of chitosan in dilute acids is often needed to be modified when specific drug release properties have to be tailored into the dosage form. The available toxicological data on chitosan and its modified forms appears to indicate its safety for oral use because high doses have been found to be tolerated well in rodents and rabbits. However, its local action as a haemostatic together with its ability to activate macrophages and cause cytokine release may require a careful assessment of its safety for parenteral use. This book offers the dynamics of chitosan's detailed composition.

Introduction; Why chitosan derivatives?; Chitosan Functionalization; Thiolated Chitosan; Tri Methylated chitosan; Highly cationic derivatives; Hydroxyalkyl chitosan; Carboxyalkyl chitosan; Cyclodextrin linked chitosan; N-Acyl chitosan; Biomedical applications of graft copolymers; Safety & toxicological studies; Conclusion; Index.

Erscheint lt. Verlag	24.2.2012
Verlagsort	New York
Sprache	englisch
Maße	230 x 155 mm
Gewicht	184 g
Themenwelt	Medizin / Pharmazie ► Pflege
Themenwelt	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
ISBN-10	1-61761-174-3 / 1617611743
ISBN-13	978-1-61761-174-2 / 9781617611742
Zustand	Neuware