The Link Between Inflammation and Cancer

Wounds that do not heal

Angus G. Dalgleish, Burkhard Haefner (Herausgeber)

Buch | Softcover

254 Seiten

2010 | Softcover reprint of hardcover 1st ed. 2006
Springer-Verlag New York Inc.
978-1-4419-3881-7 (ISBN)

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A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.

Inflammation and Cancer.- Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers.- Cytokines, NF-?B, Microenvironment, Intestinal Inflammation and Cancer.- Regulation if NF-?B Transcriptional Activity.- The Role of Immune Cells in the Tumor Microenvironment.- Tumor-Microenvironment Interactions.- CD95L/FasL and TRAIL in Tumour Surveillance and Cancer Therapy.- Infection & Neoplastic Growth 101.- Cytokines as Mediators and Targets for Cancer Cachexia.- Targeting NF-?B in Anticancer Adjunctive Chemotherapy.

Erscheint lt. Verlag	8.12.2010
Reihe/Serie	Cancer Treatment and Research ; 130
Zusatzinfo	XII, 254 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
ISBN-10	1-4419-3881-8 / 1441938818
ISBN-13	978-1-4419-3881-7 / 9781441938817
Zustand	Neuware