Microarray Image Analysis
An Algorithmic Approach
Seiten
2010
Chapman & Hall/CRC (Verlag)
978-1-4200-9153-3 (ISBN)
Chapman & Hall/CRC (Verlag)
978-1-4200-9153-3 (ISBN)
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To harness the high-throughput potential of DNA microarray technology, it is crucial that the analysis stages of the process are decoupled from the requirements of operator assistance. This book presents an automatic system for microarray image processing to make this decoupling a reality.
To harness the high-throughput potential of DNA microarray technology, it is crucial that the analysis stages of the process are decoupled from the requirements of operator assistance. Microarray Image Analysis: An Algorithmic Approach presents an automatic system for microarray image processing to make this decoupling a reality. The proposed system integrates and extends traditional analytical-based methods and custom-designed novel algorithms.
The book first explores a new technique that takes advantage of a multiview approach to image analysis and addresses the challenges of applying powerful traditional techniques, such as clustering, to full-scale microarray experiments. It then presents an effective feature identification approach, an innovative technique that renders highly detailed surface models, a new approach to subgrid detection, a novel technique for the background removal process, and a useful technique for removing "noise." The authors also develop an expectation–maximization (EM) algorithm for modeling gene regulatory networks from gene expression time series data. The final chapter describes the overall benefits of these techniques in the biological and computer sciences and reviews future research topics.
This book systematically brings together the fields of image processing, data analysis, and molecular biology to advance the state of the art in this important area. Although the text focuses on improving the processes involved in the analysis of microarray image data, the methods discussed can be applied to a broad range of medical and computer vision analysis areas.
To harness the high-throughput potential of DNA microarray technology, it is crucial that the analysis stages of the process are decoupled from the requirements of operator assistance. Microarray Image Analysis: An Algorithmic Approach presents an automatic system for microarray image processing to make this decoupling a reality. The proposed system integrates and extends traditional analytical-based methods and custom-designed novel algorithms.
The book first explores a new technique that takes advantage of a multiview approach to image analysis and addresses the challenges of applying powerful traditional techniques, such as clustering, to full-scale microarray experiments. It then presents an effective feature identification approach, an innovative technique that renders highly detailed surface models, a new approach to subgrid detection, a novel technique for the background removal process, and a useful technique for removing "noise." The authors also develop an expectation–maximization (EM) algorithm for modeling gene regulatory networks from gene expression time series data. The final chapter describes the overall benefits of these techniques in the biological and computer sciences and reviews future research topics.
This book systematically brings together the fields of image processing, data analysis, and molecular biology to advance the state of the art in this important area. Although the text focuses on improving the processes involved in the analysis of microarray image data, the methods discussed can be applied to a broad range of medical and computer vision analysis areas.
Karl Fraser is a research fellow in the Centre for Intelligent Data Analysis at Brunel University. Zidong Wang is a professor of dynamical systems and computing in the Department of Information Systems and Computing at Brunel University. Xiaohu Liu is a professor of computing and head of the Centre for Intelligent Data Analysis at Brunel University.
Introduction. Background. Data Services. Structure Extrapolation I. Structure Extrapolation II. Feature Identification I. Feature Identification II. Chained Fourier Background Reconstruction. Graph-Cutting for Improving Microarray Gene Expression. Stochastic Dynamic Modeling of Short Gene Expression Time Series Data. Conclusions. Appendices. References.
| Reihe/Serie | Chapman & Hall/CRC Computer Science & Data Analysis |
|---|---|
| Zusatzinfo | 134 Illustrations, black and white |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 589 g |
| Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 1-4200-9153-0 / 1420091530 |
| ISBN-13 | 978-1-4200-9153-3 / 9781420091533 |
| Zustand | Neuware |
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