The Essential Guide to N-of-1 Trials in Health

Jane Nikles, Geoffrey Mitchell (Herausgeber)

Buch | Softcover

245 Seiten

2016 | Softcover reprint of the original 1st ed. 2015
Springer (Verlag)
978-94-024-0440-1 (ISBN)

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N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced.

Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials.

Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Preface.- Introduction.- What are N-of-1 trials?- N-of-1 trials in the behavioural sciences.- N-of-1 trials in medical contexts.- Aggregated N-of-1 trials.- Methodological considerations for N-of-1 trials.- Randomization, allocation concealment and blinding.- Data collection and quality control.- Individual reporting of N-of-1 trials to patients and clinicians.- Assessing and reporting adverse events.- Research ethics and N-of-1 trials.- Statistical analysis of N-of-1 trials.- The economics of N-of-1 trials.- Reporting N-of-1 trials to professional audiences.- Single patient open trials.- Systematic review and meta-analysis using N-of-1 trials.- Where are N-of-1 trials headed?- Index.

Erscheinungsdatum	23.09.2017
Zusatzinfo	XI, 245 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Geisteswissenschaften ► Psychologie
	Mathematik / Informatik ► Mathematik
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Studium
Schlagworte	Behavioural interventions • clinical decision-making • N-of-1 trials • Quality Use of Medicines • Trial design
ISBN-10	94-024-0440-6 / 9402404406
ISBN-13	978-94-024-0440-1 / 9789402404401
Zustand	Neuware