Textbook of Clinical Trials (eBook)

David MacHin, Simon Day, Sylvan Green (Herausgeber)

eBook Download: PDF

2007 | 2. Auflage
784 Seiten
John Wiley & Sons (Verlag)
978-0-470-01015-0 (ISBN)

Infos

Now published in its Second Edition, the Textbook of Clinical
Trials offers detailed coverage of trial methodology in
diverse areas of medicine in a single comprehensive volume.

Praise for the First Edition:

"... very useful as an introduction to clinical research, or
for those planning specific studies within therapeutic or disease
areas." BRITISH JOURNAL OF SURGERY, Vol. 92, No. 2,
February 2005

The book's main concept is to describe the impact of
clinical trials on the practice of medicine. It separates the
information by therapeutic area because the impact of clinical
trials, the problems encountered, and the numbers of trials in
existence vary tremendously from specialty to specialty. The
sections provide a background to the disease area and general
clinical trial methodology before concentrating on particular
problems experienced in that area. Specific examples are used
throughout to address these issues.

The Textbook of Clinical Trials, Second
Edition:

* Highlights the various ways clinical trials have influenced the
practice of medicine in many therapeutic areas

* Describes the challenges posed by those conducting clinical
trials over a range of medical specialities and allied fields

* Additional therapeutic areas are included in this Second
Edition to fill gaps in the First Edition as the number
and complexity of trials increases in this rapidly developing
area

* Newly covered or updated in the Second Edition: general
surgery, plastic surgery, aesthetic surgery, palliative care,
primary care, anaesthesia and pain, transfusion, wound healing,
maternal and perinatal health, early termination, organ
transplants, ophthalmology, epilepsy, infectious disease,
neuro-oncology, adrenal, thyroid and urological cancers, as well as
a chapter on the Cochrane network

An invaluable resource for pharmaceutical companies, the
Textbook of Clinical Trials, Second Edition appeals
to those working in contract research organizations, medical
departments and in the area of public health and health science
alike.

Autor

David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore. Simon Day, Medicines and Healthcare Products Regulatory Agency, London, UK. Sylvan Green, Arizona Cancer Center, Tucson, Arizona, USA.

Inhalt

List of Contributors ix

Preface to Second Edition xvii

Preface the First Edition xix

Introduction 1

1 The Development of Clinical Trials 3
Simon Day

2 General Statistical Issues 13
David Machin

3 The Cochrane Collaboration 39
Mike Clarke

Cancer 47

4 Breast Cancer 49
Donald A. Berry, Terry L. Smith and Aman U. Buzdar

5 Childhood Cancer 63
Sharon B Murphy and Jonathan J.Shuster

6 Gastrointestinal Cancers 81
Daniel Sargent, Richard Goldberg and Paul Limburg

7 Melanoma 105
Ping-Yu Liu and Vernon K. Sondak

8 Respiratory Cancers 121
Joan H. Schiller and Kyungmann Kim

9 Adrenal Cortical Carcinoma 137
Isha Malik and Petros Perros

10 Thyroid Cancer 143
Vijayaraman Arutchelvam and Petros Perros

11 Urologic Cancers 149
Edith D. Canby-Hagino, Catherine M. Tangen, and Ian M. Thompson

12 Haematologic Cancers: Challenges in Developing New Therapeutic Approaches 167
Charles A. Schiffer and Stephen L. George

Cardiology 177

13 Acute Stroke 179
Philip Bath

14 Cardiovascular Disease 215
Krishna Prasad

Dentistry and Oral Health Care 241

15 Dentistry and Oral Health Care 243
May C.M. Wong, Colman McGrath and Edward C.M. Lo

Dermatology 261

16 Dermatology 263
Luigi Naldi and Cosetta Minelli

Infectious Diseases 287

17 HIV Infection 289
Michael D. Hughes

18 Infectious Diseases 303
Ingela Krantz

Ophthalmology 317

19 Ophthalmology 319
Jonathan C.K. Clarke and Peng-Tee Khaw

Psychiatry 333

20 Anxiety Disorders 335
M. Katherine Shear and Philip W. Lavori

21 Cognitive Behaviour Therapy 353
Nicholas Tarrier and Til Wykes

22 Psychotherapy for Depression 377
Graham Dunn

Reproductive Health 395

23 Contraception 397
Gilda Piaggio and Timothy M.M. Farley

24 Gynaecology and Infertility 421
Siladitya Bhattacharya and Jill Mollison

25 Early Pregnancy Termination 443
Beverly Winikoff and Batya Elul

26 Maternal and Perinatal Health 459
José Villar, Allan Donner, Edgardo Abalos and Liana Campódonico

Respiratory 475

27 Respiratory Medicine 477
Anders Källén

Surgery & Anaesthesia 517

28 Anaesthesia and Pain 519
Paul S. Myles and John Rigg

29 General Surgery 543
Dr Olga Jonasson and Domenic Reda

30 Plastic Surgery - Reconstructive Surgery 553
Erik Ang and Woffles Wu

31 Plastic Surgery - Aesthetic Surgery 575
Woffles Wu and Erik Ang

Transplantation 591

32 Renal Transplantation 593
Vathsala Anantharaman

Other Procedures 605

33 Wound Healing 607
Colin Song and Edwin Chan

34 Palliative Care 627
Robert S. Krouse and David Casarett

35 Complementary Medicine 647
Ping-Chung Leung

36 Cluster Randomized Trials in Health Care Research 669
Randall D. Cebul, Neal V. Dawson and Thomas E. Love

37 Nursing 681
Nicola Crichton

Special Populations 699

38 Clinical Trials in Paediatrics 701
Johan P.E. Karlberg

39 Clinical Trials Involving Older People 711
Carol Jagger and Antony J. Arthur

40 Clinical Trials in Rare Diseases 723
Simon Day

Index 735

Produkt-Details

• Erscheint lt. Verlag: 11.1.2007
• Sprache: englisch
• Themenwelt: Mathematik / Informatik ► Mathematik ► Statistik
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Technik
• Schlagworte: Biostatistics • Biostatistik • Medical Science • Medical Sciences Special Topics • Medizin • Spezialthemen Medizin • Statistics • Statistik
• ISBN-10: 0-470-01015-0 / 0470010150
• ISBN-13: 978-0-470-01015-0 / 9780470010150