Telomerase

Composition, Functions & Clinical Implications

Buch | Hardcover

159 Seiten

2011
Nova Science Publishers Inc (Verlag)
978-1-61668-957-5 (ISBN)

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Reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.

Telomerase is a ribonucleoprotein enzyme that catalyses the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential. Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumour progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.

Preface; Telomerase Beyond Telomeres: New Roles for an Old Enzyme; Telomerase & Telomeric Proteins: A Life Beyond Telomeres; Histone Deacetylase Inhibition as an Anticancer Telomerase-Targeting Strategy; Telomerase Role in Pituitary Adenomas; Regulations of Telomerase Activity & WRN Gene Expression; Telomerase & Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis; Index.

Zusatzinfo	Illustrations
Verlagsort	New York
Sprache	englisch
Maße	230 x 155 mm
Gewicht	372 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-61668-957-9 / 1616689579
ISBN-13	978-1-61668-957-5 / 9781616689575
Zustand	Neuware